Tags

Type your tag names separated by a space and hit enter

[Study on lipoprotein lipase gene Hind III polymorphism in Chinese type IIb hyperlipoproteinemia].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Dec; 20(6):539-41.ZY

Abstract

OBJECTIVE

To investigate whether lipoprotein lipase (LPL) gene Hind III polymorphism is associated with Chinese type IIb hyperlipoproteinemia.

METHODS

Lipoprotein lipase gene Hind III polymorphism was studied using polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) in 103 type IIb hyperlipoproteinemia patients and 129 healthy subjects from a population of Chinese Hans in Chengdu area.

RESULTS

Both in type IIb hyperlipoproteinemia group and control group, the H+H+ homozygote was the major allelotype. The H+ allelic frequency of type IIb hyperlipoproteinemia group was higher than that of control group (0.864 vs 0.705, P<0.01). But the H- allelic frequency of type IIb hyperlipoproteinemia group was significantly lower than that of control group (0.136 vs 0.295, P<0.01). The plasma triglycerides (TG) level of H+H+ genotype was significantly higher than that of H+H- and H-H- genotypes (P<0.05 and P<0.01); the plasma TC level and TG/HDL C ratio were higher than those of H+H- and H-H- genotypes (P<0.05); apoA II levels of H+H+ and H+H- genotypes were significantly lower than that of H-H- genotype (P<0.01 and P<0.05).

CONCLUSION

The Hind III RFLP at intron 8 of LPL gene is associated with type II b hyperlipoproteinemia to some extent in Chinese population.

Authors+Show Affiliations

Department of Biochemistry and Apolipoprotein Research Unit, Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041 PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14669227

Citation

Zhang, Rong, et al. "[Study On Lipoprotein Lipase Gene Hind III Polymorphism in Chinese Type IIb Hyperlipoproteinemia]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 20, no. 6, 2003, pp. 539-41.
Zhang R, Liu Y, Yang LC, et al. [Study on lipoprotein lipase gene Hind III polymorphism in Chinese type IIb hyperlipoproteinemia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20(6):539-41.
Zhang, R., Liu, Y., Yang, L. C., Bai, H., & Liu, B. W. (2003). [Study on lipoprotein lipase gene Hind III polymorphism in Chinese type IIb hyperlipoproteinemia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 20(6), 539-41.
Zhang R, et al. [Study On Lipoprotein Lipase Gene Hind III Polymorphism in Chinese Type IIb Hyperlipoproteinemia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20(6):539-41. PubMed PMID: 14669227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on lipoprotein lipase gene Hind III polymorphism in Chinese type IIb hyperlipoproteinemia]. AU - Zhang,Rong, AU - Liu,Yu, AU - Yang,Lu-chuan, AU - Bai,Huai, AU - Liu,Bing-wen, PY - 2003/12/12/pubmed PY - 2004/4/16/medline PY - 2003/12/12/entrez SP - 539 EP - 41 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 20 IS - 6 N2 - OBJECTIVE: To investigate whether lipoprotein lipase (LPL) gene Hind III polymorphism is associated with Chinese type IIb hyperlipoproteinemia. METHODS: Lipoprotein lipase gene Hind III polymorphism was studied using polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) in 103 type IIb hyperlipoproteinemia patients and 129 healthy subjects from a population of Chinese Hans in Chengdu area. RESULTS: Both in type IIb hyperlipoproteinemia group and control group, the H+H+ homozygote was the major allelotype. The H+ allelic frequency of type IIb hyperlipoproteinemia group was higher than that of control group (0.864 vs 0.705, P<0.01). But the H- allelic frequency of type IIb hyperlipoproteinemia group was significantly lower than that of control group (0.136 vs 0.295, P<0.01). The plasma triglycerides (TG) level of H+H+ genotype was significantly higher than that of H+H- and H-H- genotypes (P<0.05 and P<0.01); the plasma TC level and TG/HDL C ratio were higher than those of H+H- and H-H- genotypes (P<0.05); apoA II levels of H+H+ and H+H- genotypes were significantly lower than that of H-H- genotype (P<0.01 and P<0.05). CONCLUSION: The Hind III RFLP at intron 8 of LPL gene is associated with type II b hyperlipoproteinemia to some extent in Chinese population. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/14669227/[Study_on_lipoprotein_lipase_gene_Hind_III_polymorphism_in_Chinese_type_IIb_hyperlipoproteinemia]_ DB - PRIME DP - Unbound Medicine ER -