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Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa.
Phytother Res. 2003 Dec; 17(10):1155-7.PR

Abstract

The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 microg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and significant antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 microg/mL.

Authors+Show Affiliations

Mosaddik MA
Centre for Phytochemistry, Southern Cross University, Lismore, NSW 2480, Australia. mamosaddik@yahoo.com
Haque ME
No affiliation info available

MeSH

AnimalsAnti-Infective AgentsArtemiaBacillus cereusCucurbitaceaeDose-Response Relationship, DrugGram-Negative BacteriaGram-Positive BacteriaLethal Dose 50Microbial Sensitivity TestsMitosporic FungiPhytotherapyPlant ExtractsPyronesShigella

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14669248

Citation

Mosaddik, M Ashik, and M Ekramul Haque. "Cytotoxicity and Antimicrobial Activity of Goniothalamin Isolated From Bryonopsis Laciniosa." Phytotherapy Research : PTR, vol. 17, no. 10, 2003, pp. 1155-7.
Mosaddik MA, Haque ME. Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa. Phytother Res. 2003;17(10):1155-7.
Mosaddik, M. A., & Haque, M. E. (2003). Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa. Phytotherapy Research : PTR, 17(10), 1155-7.
Mosaddik MA, Haque ME. Cytotoxicity and Antimicrobial Activity of Goniothalamin Isolated From Bryonopsis Laciniosa. Phytother Res. 2003;17(10):1155-7. PubMed PMID: 14669248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa. AU - Mosaddik,M Ashik, AU - Haque,M Ekramul, PY - 2003/12/12/pubmed PY - 2004/2/27/medline PY - 2003/12/12/entrez SP - 1155 EP - 7 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 10 N2 - The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 microg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and significant antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 microg/mL. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/14669248/Cytotoxicity_and_antimicrobial_activity_of_goniothalamin_isolated_from_Bryonopsis_laciniosa_ DB - PRIME DP - Unbound Medicine ER -