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Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem.
Phytother Res. 2003 Dec; 17(10):1177-81.PR

Abstract

Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula stem, which showed promising antibacterial activity against thirteen Gram-positive and nine Gram-negative organisms, furnished (3S,4R)-3,4,5-trihydroxypentanoic acid-1,4-lactone (1) as the active principle. The structure of (1) was established by UV, IR, mass, 1H and 13C NMR as well as 2D NMR spectral studies and the formation of its acetate (1a). On acetylation activity of (1) was markedly reduced. It is synthetically well known and only recently isolated from two plants, however, its antimicrobial activity was not reported earlier. The extract, fractions and pure compounds did not show any remarkable activity against fungi and Mycobacterium fortuitum, and M. smegmatis.

Authors+Show Affiliations

Faizi S
H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. shaheen@khi.comsats.net.pk
Mughal NR
No affiliation info available
Khan RA
No affiliation info available
Khan SA
No affiliation info available
Ahmad A
No affiliation info available
Bibi N
No affiliation info available
Ahmed SA
No affiliation info available

MeSH

Anti-Infective AgentsGram-Negative BacteriaGram-Positive BacteriaHumansLactonesMicrobial Sensitivity TestsMitosporic FungiMycobacteriumPhytotherapyPlant ExtractsPlant StemsPolyalthia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14669252

Citation

Faizi, Shaheen, et al. "Evaluation of the Antimicrobial Property of Polyalthia Longifolia Var. Pendula: Isolation of a Lactone as the Active Antibacterial Agent From the Ethanol Extract of the Stem." Phytotherapy Research : PTR, vol. 17, no. 10, 2003, pp. 1177-81.
Faizi S, Mughal NR, Khan RA, et al. Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem. Phytother Res. 2003;17(10):1177-81.
Faizi, S., Mughal, N. R., Khan, R. A., Khan, S. A., Ahmad, A., Bibi, N., & Ahmed, S. A. (2003). Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem. Phytotherapy Research : PTR, 17(10), 1177-81.
Faizi S, et al. Evaluation of the Antimicrobial Property of Polyalthia Longifolia Var. Pendula: Isolation of a Lactone as the Active Antibacterial Agent From the Ethanol Extract of the Stem. Phytother Res. 2003;17(10):1177-81. PubMed PMID: 14669252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem. AU - Faizi,Shaheen, AU - Mughal,Najma Rasool, AU - Khan,Rashid Ali, AU - Khan,Shakeel Ahmed, AU - Ahmad,Aqeel, AU - Bibi,Nazia, AU - Ahmed,Shaheena Anwar, PY - 2003/12/12/pubmed PY - 2004/2/27/medline PY - 2003/12/12/entrez SP - 1177 EP - 81 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 10 N2 - Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula stem, which showed promising antibacterial activity against thirteen Gram-positive and nine Gram-negative organisms, furnished (3S,4R)-3,4,5-trihydroxypentanoic acid-1,4-lactone (1) as the active principle. The structure of (1) was established by UV, IR, mass, 1H and 13C NMR as well as 2D NMR spectral studies and the formation of its acetate (1a). On acetylation activity of (1) was markedly reduced. It is synthetically well known and only recently isolated from two plants, however, its antimicrobial activity was not reported earlier. The extract, fractions and pure compounds did not show any remarkable activity against fungi and Mycobacterium fortuitum, and M. smegmatis. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/14669252/Evaluation_of_the_antimicrobial_property_of_Polyalthia_longifolia_var__pendula:_isolation_of_a_lactone_as_the_active_antibacterial_agent_from_the_ethanol_extract_of_the_stem_ DB - PRIME DP - Unbound Medicine ER -