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Opioid receptors regulate the extinction of Pavlovian fear conditioning.
Behav Neurosci. 2003 Dec; 117(6):1292-301.BN

Abstract

Rats received a single pairing of an auditory conditioned stimulus (CS) with a footshock unconditioned stimulus (US). The fear (freezing) that had accrued to the CS was then extinguished. Injection of naloxone prior to this extinction significantly impaired the development of extinction. This impairment was mediated by opioid receptors in the brain and was not observed when naloxone was injected after extinction training. Finally, an injection of naloxone on test failed to reinstate extinguished responding that had already accrued to the CS. These experiments show that opioid receptors regulate the development, but not the expression, of fear extinction and are discussed with reference to the roles of opioid receptors in US processing, memory, and appetitive motivation.

Authors+Show Affiliations

School of Psychology, University of New South Wales, Sydney, New South Wales, Australia. g.mcnally@unsw.edu.auNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14674848

Citation

McNally, Gavan P., and R Frederick Westbrook. "Opioid Receptors Regulate the Extinction of Pavlovian Fear Conditioning." Behavioral Neuroscience, vol. 117, no. 6, 2003, pp. 1292-301.
McNally GP, Westbrook RF. Opioid receptors regulate the extinction of Pavlovian fear conditioning. Behav Neurosci. 2003;117(6):1292-301.
McNally, G. P., & Westbrook, R. F. (2003). Opioid receptors regulate the extinction of Pavlovian fear conditioning. Behavioral Neuroscience, 117(6), 1292-301.
McNally GP, Westbrook RF. Opioid Receptors Regulate the Extinction of Pavlovian Fear Conditioning. Behav Neurosci. 2003;117(6):1292-301. PubMed PMID: 14674848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioid receptors regulate the extinction of Pavlovian fear conditioning. AU - McNally,Gavan P, AU - Westbrook,R Frederick, PY - 2003/12/17/pubmed PY - 2004/3/3/medline PY - 2003/12/17/entrez SP - 1292 EP - 301 JF - Behavioral neuroscience JO - Behav Neurosci VL - 117 IS - 6 N2 - Rats received a single pairing of an auditory conditioned stimulus (CS) with a footshock unconditioned stimulus (US). The fear (freezing) that had accrued to the CS was then extinguished. Injection of naloxone prior to this extinction significantly impaired the development of extinction. This impairment was mediated by opioid receptors in the brain and was not observed when naloxone was injected after extinction training. Finally, an injection of naloxone on test failed to reinstate extinguished responding that had already accrued to the CS. These experiments show that opioid receptors regulate the development, but not the expression, of fear extinction and are discussed with reference to the roles of opioid receptors in US processing, memory, and appetitive motivation. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/14674848/Opioid_receptors_regulate_the_extinction_of_Pavlovian_fear_conditioning_ L2 - http://content.apa.org/journals/bne/117/6/1292 DB - PRIME DP - Unbound Medicine ER -