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Deficient spatial memory induced by blockade of beta-adrenoceptors in the hippocampal CA1 region.
Behav Neurosci. 2003 Dec; 117(6):1378-84.BN

Abstract

A previous study showed that intra-CAl infusion of the beta-adrenergic antagonist DL-propranolol interfered with consolidation of memory for contextual fear conditioning (J.-Z. Ji, X.-M. Wang, & B.-M. Li, 2003). The present study investigated the effect of similarly administered DL-propranolol on consolidation of spatial memory for the water maze. DL-propranolol infused 5 min, but not 6 hr, posttraining caused a deficit in 48-hr memory for the spatial water maze task, whereas similarly administered D-propranolol, which has an equipotent "local-anesthetic" activity but significantly lower beta-blocking activity, induced no amnesia. However, DL-propranolol administered 5 min posttraining did not impair 48-hr memory for the cued water maze task. Thus, beta-adrenoceptor in area CA1 is involved in regulating consolidation of spatial memory for the water maze.

Authors+Show Affiliations

Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, Shanghai, The People's Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14674855

Citation

Ji, J-Z, et al. "Deficient Spatial Memory Induced By Blockade of Beta-adrenoceptors in the Hippocampal CA1 Region." Behavioral Neuroscience, vol. 117, no. 6, 2003, pp. 1378-84.
Ji JZ, Zhang XH, Li BM. Deficient spatial memory induced by blockade of beta-adrenoceptors in the hippocampal CA1 region. Behav Neurosci. 2003;117(6):1378-84.
Ji, J. Z., Zhang, X. H., & Li, B. M. (2003). Deficient spatial memory induced by blockade of beta-adrenoceptors in the hippocampal CA1 region. Behavioral Neuroscience, 117(6), 1378-84.
Ji JZ, Zhang XH, Li BM. Deficient Spatial Memory Induced By Blockade of Beta-adrenoceptors in the Hippocampal CA1 Region. Behav Neurosci. 2003;117(6):1378-84. PubMed PMID: 14674855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deficient spatial memory induced by blockade of beta-adrenoceptors in the hippocampal CA1 region. AU - Ji,J-Z, AU - Zhang,X-H, AU - Li,B-M, PY - 2003/12/17/pubmed PY - 2004/3/3/medline PY - 2003/12/17/entrez SP - 1378 EP - 84 JF - Behavioral neuroscience JO - Behav Neurosci VL - 117 IS - 6 N2 - A previous study showed that intra-CAl infusion of the beta-adrenergic antagonist DL-propranolol interfered with consolidation of memory for contextual fear conditioning (J.-Z. Ji, X.-M. Wang, & B.-M. Li, 2003). The present study investigated the effect of similarly administered DL-propranolol on consolidation of spatial memory for the water maze. DL-propranolol infused 5 min, but not 6 hr, posttraining caused a deficit in 48-hr memory for the spatial water maze task, whereas similarly administered D-propranolol, which has an equipotent "local-anesthetic" activity but significantly lower beta-blocking activity, induced no amnesia. However, DL-propranolol administered 5 min posttraining did not impair 48-hr memory for the cued water maze task. Thus, beta-adrenoceptor in area CA1 is involved in regulating consolidation of spatial memory for the water maze. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/14674855/Deficient_spatial_memory_induced_by_blockade_of_beta_adrenoceptors_in_the_hippocampal_CA1_region_ L2 - http://content.apa.org/journals/bne/117/6/1378 DB - PRIME DP - Unbound Medicine ER -