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Castration reduces the effect of serotonin-1A receptor stimulation on prepulse inhibition in rats.
Behav Neurosci. 2003 Dec; 117(6):1407-15.BN

Abstract

This study examined the interaction between hormones and serotonin-1A (5-HT1A) receptor modulation of prepulse inhibition (PPI) of the acoustic startle response. Male and female rats were gonadectomized; some castrated rats received testosterone- or estrogen-filled implants. Rats were randomly injected with saline or 0.02 or 0.50 mg/kg 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist. All rats showed a dose-dependent disruption of PPI in response to 8-OH-DPAT. In untreated castrated rats, this disruption was significantly reduced (33% compared with 78% in sham-operated rats). Testosterone treatment reversed this reduction, but estrogen was less effective. Ovariectomized and sham-operated rats showed similar PPI in response to 8-OH-DPAT. These data suggest that the effect of 8-OH-DPAT on PPI in male rats depends on circulating hormone levels, particularly testosterone.

Authors+Show Affiliations

Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Victoria, Australia.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14674858

Citation

Gogos, Andrea, and Maarten van den Buuse. "Castration Reduces the Effect of serotonin-1A Receptor Stimulation On Prepulse Inhibition in Rats." Behavioral Neuroscience, vol. 117, no. 6, 2003, pp. 1407-15.
Gogos A, van den Buuse M. Castration reduces the effect of serotonin-1A receptor stimulation on prepulse inhibition in rats. Behav Neurosci. 2003;117(6):1407-15.
Gogos, A., & van den Buuse, M. (2003). Castration reduces the effect of serotonin-1A receptor stimulation on prepulse inhibition in rats. Behavioral Neuroscience, 117(6), 1407-15.
Gogos A, van den Buuse M. Castration Reduces the Effect of serotonin-1A Receptor Stimulation On Prepulse Inhibition in Rats. Behav Neurosci. 2003;117(6):1407-15. PubMed PMID: 14674858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Castration reduces the effect of serotonin-1A receptor stimulation on prepulse inhibition in rats. AU - Gogos,Andrea, AU - van den Buuse,Maarten, PY - 2003/12/17/pubmed PY - 2004/3/3/medline PY - 2003/12/17/entrez SP - 1407 EP - 15 JF - Behavioral neuroscience JO - Behav Neurosci VL - 117 IS - 6 N2 - This study examined the interaction between hormones and serotonin-1A (5-HT1A) receptor modulation of prepulse inhibition (PPI) of the acoustic startle response. Male and female rats were gonadectomized; some castrated rats received testosterone- or estrogen-filled implants. Rats were randomly injected with saline or 0.02 or 0.50 mg/kg 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist. All rats showed a dose-dependent disruption of PPI in response to 8-OH-DPAT. In untreated castrated rats, this disruption was significantly reduced (33% compared with 78% in sham-operated rats). Testosterone treatment reversed this reduction, but estrogen was less effective. Ovariectomized and sham-operated rats showed similar PPI in response to 8-OH-DPAT. These data suggest that the effect of 8-OH-DPAT on PPI in male rats depends on circulating hormone levels, particularly testosterone. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/14674858/Castration_reduces_the_effect_of_serotonin_1A_receptor_stimulation_on_prepulse_inhibition_in_rats_ L2 - http://content.apa.org/journals/bne/117/6/1407 DB - PRIME DP - Unbound Medicine ER -