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Shanxi Province cervical cancer screening study II: self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology.
Int J Gynecol Cancer. 2003 Nov-Dec; 13(6):819-26.IJ

Abstract

The objective of this study was to compare the sensitivity and specificity of a new method for self-sampling for high risk human papillomavirus (HPV) with direct sampling and liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27-56) underwent a self-sample for HPV using a conical-shaped brush placed into the upper vagina and rotated. Three to sixteen months later the women were screened with liquid-based cytology and direct HPV tests. Subjects with any abnormal test underwent colposcopy and multiple biopsies. Mean age was 40.9 years. 4.4 percent of subjects had >or=CIN II, 26% a positive self-sample and 24% a positive direct test for HPV. The sensitivity for detection of >or=CIN II was 87.5% for self-sampling, and 96.8% for the direct test (P < 0.001). The specificity was 77.2% for the self-sample and 79.7% for the direct test. With an abnormal Pap defined as ASCUS or greater the sensitivity of the Pap for the detection of >CIN II was 88.3% and the specificity was 81.2%. We conclude that self-sampling for HPV is less sensitive for >CIN II than the direct test, but similar to liquid based cytology.

Authors+Show Affiliations

Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. belinsj@ccf.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

14675319

Citation

Belinson, J L., et al. "Shanxi Province Cervical Cancer Screening Study II: Self-sampling for High-risk Human Papillomavirus Compared to Direct Sampling for Human Papillomavirus and Liquid Based Cervical Cytology." International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, vol. 13, no. 6, 2003, pp. 819-26.
Belinson JL, Qiao YL, Pretorius RG, et al. Shanxi Province cervical cancer screening study II: self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology. Int J Gynecol Cancer. 2003;13(6):819-26.
Belinson, J. L., Qiao, Y. L., Pretorius, R. G., Zhang, W. H., Rong, S. D., Huang, M. N., Zhao, F. H., Wu, L. Y., Ren, S. D., Huang, R. D., Washington, M. F., Pan, Q. J., Li, L., & Fife, D. (2003). Shanxi Province cervical cancer screening study II: self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, 13(6), 819-26.
Belinson JL, et al. Shanxi Province Cervical Cancer Screening Study II: Self-sampling for High-risk Human Papillomavirus Compared to Direct Sampling for Human Papillomavirus and Liquid Based Cervical Cytology. Int J Gynecol Cancer. 2003 Nov-Dec;13(6):819-26. PubMed PMID: 14675319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shanxi Province cervical cancer screening study II: self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology. AU - Belinson,J L, AU - Qiao,Y L, AU - Pretorius,R G, AU - Zhang,W H, AU - Rong,S D, AU - Huang,M N, AU - Zhao,F H, AU - Wu,L Y, AU - Ren,S D, AU - Huang,R D, AU - Washington,M F, AU - Pan,Q J, AU - Li,L, AU - Fife,D, PY - 2003/12/17/pubmed PY - 2004/3/31/medline PY - 2003/12/17/entrez SP - 819 EP - 26 JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society JO - Int. J. Gynecol. Cancer VL - 13 IS - 6 N2 - The objective of this study was to compare the sensitivity and specificity of a new method for self-sampling for high risk human papillomavirus (HPV) with direct sampling and liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27-56) underwent a self-sample for HPV using a conical-shaped brush placed into the upper vagina and rotated. Three to sixteen months later the women were screened with liquid-based cytology and direct HPV tests. Subjects with any abnormal test underwent colposcopy and multiple biopsies. Mean age was 40.9 years. 4.4 percent of subjects had >or=CIN II, 26% a positive self-sample and 24% a positive direct test for HPV. The sensitivity for detection of >or=CIN II was 87.5% for self-sampling, and 96.8% for the direct test (P < 0.001). The specificity was 77.2% for the self-sample and 79.7% for the direct test. With an abnormal Pap defined as ASCUS or greater the sensitivity of the Pap for the detection of >CIN II was 88.3% and the specificity was 81.2%. We conclude that self-sampling for HPV is less sensitive for >CIN II than the direct test, but similar to liquid based cytology. SN - 1048-891X UR - https://www.unboundmedicine.com/medline/citation/14675319/Shanxi_Province_cervical_cancer_screening_study_II:_self_sampling_for_high_risk_human_papillomavirus_compared_to_direct_sampling_for_human_papillomavirus_and_liquid_based_cervical_cytology_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=1048-891X&amp;date=2003&amp;volume=13&amp;issue=6&amp;spage=819 DB - PRIME DP - Unbound Medicine ER -