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Anterior spinal artery syndrome complicated by the ondine curse.
Arch Neurol. 2003 Dec; 60(12):1787-90.AN

Abstract

BACKGROUND

Anterior spinal artery (ASA) syndrome results in motor palsy and dissociated sensory loss below the level of the lesion, accompanied by bladder dysfunction. When the cervical spine is involved, breathing disorders may be observed.

OBJECTIVE

To describe the polysomnographic findings in a patient with cervical ASA syndrome complicated by a sleep breathing disorder.

SETTING

Unit of neurology at a sleep center. Patient A 30-year-old man had an ischemic lesion that affected the anterior cervical spinal cord (C2-C6) bilaterally because of an ASA thrombosis. He developed ASA syndrome associated with respiratory impairment during sleep.

RESULTS

The polysomnographic study during sleep showed a severe sleep disruption caused by continuous central apneas that appeared immediately after falling asleep. Treatment by intermittent positive pressure ventilation normalized the respiratory pattern and sleep architecture.

CONCLUSIONS

The sleep breathing pattern was compatible with central alveolar hypoventilation due to automatic breathing control failure caused by a lesion of the reticulospinal pathway, which normally activates ventilatory muscles during sleep. This autonomic sleep breathing impairment resembles that found as a complication in patients who undergo spinothalamic tract cervical cordotomy for intractable pain. This surgical complication is known as the Ondine curse.

Authors+Show Affiliations

Units of Neurology, St Orsola-Malpighi Hospital, Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

14676058

Citation

Manconi, Mauro, et al. "Anterior Spinal Artery Syndrome Complicated By the Ondine Curse." Archives of Neurology, vol. 60, no. 12, 2003, pp. 1787-90.
Manconi M, Mondini S, Fabiani A, et al. Anterior spinal artery syndrome complicated by the ondine curse. Arch Neurol. 2003;60(12):1787-90.
Manconi, M., Mondini, S., Fabiani, A., Rossi, P., Ambrosetto, P., & Cirignotta, F. (2003). Anterior spinal artery syndrome complicated by the ondine curse. Archives of Neurology, 60(12), 1787-90.
Manconi M, et al. Anterior Spinal Artery Syndrome Complicated By the Ondine Curse. Arch Neurol. 2003;60(12):1787-90. PubMed PMID: 14676058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anterior spinal artery syndrome complicated by the ondine curse. AU - Manconi,Mauro, AU - Mondini,Susanna, AU - Fabiani,Andrea, AU - Rossi,Paolo, AU - Ambrosetto,Paolo, AU - Cirignotta,Fabio, PY - 2003/12/17/pubmed PY - 2004/1/8/medline PY - 2003/12/17/entrez SP - 1787 EP - 90 JF - Archives of neurology JO - Arch Neurol VL - 60 IS - 12 N2 - BACKGROUND: Anterior spinal artery (ASA) syndrome results in motor palsy and dissociated sensory loss below the level of the lesion, accompanied by bladder dysfunction. When the cervical spine is involved, breathing disorders may be observed. OBJECTIVE: To describe the polysomnographic findings in a patient with cervical ASA syndrome complicated by a sleep breathing disorder. SETTING: Unit of neurology at a sleep center. Patient A 30-year-old man had an ischemic lesion that affected the anterior cervical spinal cord (C2-C6) bilaterally because of an ASA thrombosis. He developed ASA syndrome associated with respiratory impairment during sleep. RESULTS: The polysomnographic study during sleep showed a severe sleep disruption caused by continuous central apneas that appeared immediately after falling asleep. Treatment by intermittent positive pressure ventilation normalized the respiratory pattern and sleep architecture. CONCLUSIONS: The sleep breathing pattern was compatible with central alveolar hypoventilation due to automatic breathing control failure caused by a lesion of the reticulospinal pathway, which normally activates ventilatory muscles during sleep. This autonomic sleep breathing impairment resembles that found as a complication in patients who undergo spinothalamic tract cervical cordotomy for intractable pain. This surgical complication is known as the Ondine curse. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/14676058/Anterior_spinal_artery_syndrome_complicated_by_the_ondine_curse_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/60/pg/1787 DB - PRIME DP - Unbound Medicine ER -