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Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation.
Bone Marrow Transplant. 2004 Feb; 33(4):431-4.BM

Abstract

To evaluate the clinical significance of a cytomegalovirus (CMV) antigenemia assay in the prediction and diagnosis of CMV gastrointestinal (CMV-GI) disease after hematopoietic stem cell transplantation (HSCT), 19 allogeneic HSCT recipients developing CMV-GI disease were retrospectively reviewed. All patients were monitored by a CMV antigenemia assay, at least once weekly after engraftment. The median onset of CMV-GI disease occurred 31 days post transplant (range: 19-62). Only four of 19 patients (21%) developed a positive CMV antigenemia test before developing CMV-GI diseases. Although all 19 patients subsequently developed positive CMV antigenemia tests during their clinical courses, the values remained at a low-level in nine (47%) patients. Among the 14 patients in whom results of real-time polymerase chain reaction (PCR) were available, seven (50%) yielded positive results of real-time PCR before developing CMV-GI disease. In contrast to the values of CMV antigenemia, all 14 patients exclusively yielded high viral loads (median: 2.8 x 10(4) copies/ml plasma). We conclude that CMV antigenemia testing has limited value in prediction or early diagnosis of CMV-GI disease, and that real-time PCR could have a more diagnostic significance.

Authors+Show Affiliations

Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. tmori@sc.itc.keio.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

14676775

Citation

Mori, T, et al. "Clinical Significance of Cytomegalovirus (CMV) Antigenemia in the Prediction and Diagnosis of CMV Gastrointestinal Disease After Allogeneic Hematopoietic Stem Cell Transplantation." Bone Marrow Transplantation, vol. 33, no. 4, 2004, pp. 431-4.
Mori T, Mori S, Kanda Y, et al. Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2004;33(4):431-4.
Mori, T., Mori, S., Kanda, Y., Yakushiji, K., Mineishi, S., Takaue, Y., Gondo, H., Harada, M., Sakamaki, H., Yajima, T., Iwao, Y., Hibi, T., & Okamoto, S. (2004). Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation, 33(4), 431-4.
Mori T, et al. Clinical Significance of Cytomegalovirus (CMV) Antigenemia in the Prediction and Diagnosis of CMV Gastrointestinal Disease After Allogeneic Hematopoietic Stem Cell Transplantation. Bone Marrow Transplant. 2004;33(4):431-4. PubMed PMID: 14676775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation. AU - Mori,T, AU - Mori,S, AU - Kanda,Y, AU - Yakushiji,K, AU - Mineishi,S, AU - Takaue,Y, AU - Gondo,H, AU - Harada,M, AU - Sakamaki,H, AU - Yajima,T, AU - Iwao,Y, AU - Hibi,T, AU - Okamoto,S, PY - 2003/12/17/pubmed PY - 2004/10/1/medline PY - 2003/12/17/entrez SP - 431 EP - 4 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 33 IS - 4 N2 - To evaluate the clinical significance of a cytomegalovirus (CMV) antigenemia assay in the prediction and diagnosis of CMV gastrointestinal (CMV-GI) disease after hematopoietic stem cell transplantation (HSCT), 19 allogeneic HSCT recipients developing CMV-GI disease were retrospectively reviewed. All patients were monitored by a CMV antigenemia assay, at least once weekly after engraftment. The median onset of CMV-GI disease occurred 31 days post transplant (range: 19-62). Only four of 19 patients (21%) developed a positive CMV antigenemia test before developing CMV-GI diseases. Although all 19 patients subsequently developed positive CMV antigenemia tests during their clinical courses, the values remained at a low-level in nine (47%) patients. Among the 14 patients in whom results of real-time polymerase chain reaction (PCR) were available, seven (50%) yielded positive results of real-time PCR before developing CMV-GI disease. In contrast to the values of CMV antigenemia, all 14 patients exclusively yielded high viral loads (median: 2.8 x 10(4) copies/ml plasma). We conclude that CMV antigenemia testing has limited value in prediction or early diagnosis of CMV-GI disease, and that real-time PCR could have a more diagnostic significance. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/14676775/Clinical_significance_of_cytomegalovirus__CMV__antigenemia_in_the_prediction_and_diagnosis_of_CMV_gastrointestinal_disease_after_allogeneic_hematopoietic_stem_cell_transplantation_ L2 - https://doi.org/10.1038/sj.bmt.1704369 DB - PRIME DP - Unbound Medicine ER -