Tags

Type your tag names separated by a space and hit enter

Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders.
Pharmacopsychiatry. 2003 Nov; 36 Suppl 3:S250-4.P

Abstract

Bipolar disorder is increasingly recognized as an illness that may progress to impairment in neurocognitive functioning and cell loss in cortical and limbic brain regions. Glutamatergic damage and/or damage due to high glucocorticoid levels that inhibit adult neurogenesis are likely contributing mechanisms. Drug treatments with possible neuroprotective effects are becoming increasingly important both clinically and as research tools. Mood stabilizing drugs and lithium in particular may act to prevent neuronal damage and tissue loss that may occur in the brain of patients with bipolar disorders. Lithium has been shown to exert neuroprotective effects in vitro and to stimulate neurogenesis in the hippocampus. Animal studies have demonstrated pharmacological effects of lithium suggestive of its role in neuroprotection, which range from reducing excitotoxicity through increased glutamate uptake, to regulation of a number of signal transduction intermediates such as myo-inositol, protein kinase C, phosphotidylinositol-3 kinase (PI-3K)/protein kinase B (Akt), ras-mitogen-activated protein kinase (MAPK), glycogen synthase kinase (GSK)-3alpha and -3beta and calcium. It remains to be established whether lithium treatment protects against possible cell damage in the same manner as it protects against recurrences of the illness. We propose to examine the effect of long-term lithium treatment on neurocognitive functioning of bipolar patients and the use of lithium in the treatment of chronic neuropsychiatric disorders.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Charité - University Medicine Berlin, Campus Charité-Mitte (CCM), Berlin, Germany. michael.bauer@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14677087

Citation

Bauer, M, et al. "Implications of the Neuroprotective Effects of Lithium for the Treatment of Bipolar and Neurodegenerative Disorders." Pharmacopsychiatry, vol. 36 Suppl 3, 2003, pp. S250-4.
Bauer M, Alda M, Priller J, et al. Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders. Pharmacopsychiatry. 2003;36 Suppl 3:S250-4.
Bauer, M., Alda, M., Priller, J., & Young, L. T. (2003). Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders. Pharmacopsychiatry, 36 Suppl 3, S250-4.
Bauer M, et al. Implications of the Neuroprotective Effects of Lithium for the Treatment of Bipolar and Neurodegenerative Disorders. Pharmacopsychiatry. 2003;36 Suppl 3:S250-4. PubMed PMID: 14677087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders. AU - Bauer,M, AU - Alda,M, AU - Priller,J, AU - Young,L T, AU - ,, PY - 2003/12/17/pubmed PY - 2004/2/28/medline PY - 2003/12/17/entrez SP - S250 EP - 4 JF - Pharmacopsychiatry JO - Pharmacopsychiatry VL - 36 Suppl 3 N2 - Bipolar disorder is increasingly recognized as an illness that may progress to impairment in neurocognitive functioning and cell loss in cortical and limbic brain regions. Glutamatergic damage and/or damage due to high glucocorticoid levels that inhibit adult neurogenesis are likely contributing mechanisms. Drug treatments with possible neuroprotective effects are becoming increasingly important both clinically and as research tools. Mood stabilizing drugs and lithium in particular may act to prevent neuronal damage and tissue loss that may occur in the brain of patients with bipolar disorders. Lithium has been shown to exert neuroprotective effects in vitro and to stimulate neurogenesis in the hippocampus. Animal studies have demonstrated pharmacological effects of lithium suggestive of its role in neuroprotection, which range from reducing excitotoxicity through increased glutamate uptake, to regulation of a number of signal transduction intermediates such as myo-inositol, protein kinase C, phosphotidylinositol-3 kinase (PI-3K)/protein kinase B (Akt), ras-mitogen-activated protein kinase (MAPK), glycogen synthase kinase (GSK)-3alpha and -3beta and calcium. It remains to be established whether lithium treatment protects against possible cell damage in the same manner as it protects against recurrences of the illness. We propose to examine the effect of long-term lithium treatment on neurocognitive functioning of bipolar patients and the use of lithium in the treatment of chronic neuropsychiatric disorders. SN - 0176-3679 UR - https://www.unboundmedicine.com/medline/citation/14677087/Implications_of_the_neuroprotective_effects_of_lithium_for_the_treatment_of_bipolar_and_neurodegenerative_disorders_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-45138 DB - PRIME DP - Unbound Medicine ER -