Tags

Type your tag names separated by a space and hit enter

A comparative study of the effects of gestodene 60 microg/ethinylestradiol 15 microg and desogestrel 150 microg/ethinylestradiol 20 microg on hemostatic balance, blood lipid levels and carbohydrate metabolism.
Eur J Contracept Reprod Health Care. 1999 Nov; 4 Suppl 2:27-35.EJ

Abstract

OBJECTIVES

This multicenter, randomized, parallel-group, open-label study was conducted to compare the effects of gestodene (GTD) 60 microg/ethinylestradiol (EE) 15 microg and desogestrel (DSG) 150 microg/EE 20 microg (Mercilon) on selected metabolic measurements during six cycles in 124 healthy women.

METHODS

GTD/EE subjects received a single pill once daily from days 1 to 24 of a 28-day cycle, followed by placebo pills daily for the last 4 days of the cycle. DSG/EE subjects received a single pill daily from days 1 to 21 of a 28-day cycle, followed by a 7-day pill-free interval. Safety was assessed from changes in hemostatic measurements, lipid profile, glucose tolerance and adverse events.

RESULTS

Both GTD/EE and DSG/EE groups exhibited minimal effects on the lipid profile. An increased glucose response was noted with both treatments and an increased insulin response was noted with GTD/EE. Hemostatic activity was increased in both groups but a counteracting increase in fibrinolytic activity occurred together with an increase in coagulatory activity. The incidence of adverse events was comparable between groups, and no significant differences in cycle control were observed between groups. No pregnancies occurred in either group.

CONCLUSIONS

The 24-day GTD 60 microg/EE 15 microg formulation and DSG/EE produced similar effects on hemostatic balance, lipid metabolism and glucose tolerance, and exhibited comparable efficacy and tolerability.

Authors+Show Affiliations

Academisch Ziekenhuis, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Clinical Trial, Phase III
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

14677622

Citation

van der Mooren, M J., et al. "A Comparative Study of the Effects of Gestodene 60 Microg/ethinylestradiol 15 Microg and Desogestrel 150 Microg/ethinylestradiol 20 Microg On Hemostatic Balance, Blood Lipid Levels and Carbohydrate Metabolism." The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, vol. 4 Suppl 2, 1999, pp. 27-35.
van der Mooren MJ, Klipping C, van Aken B, et al. A comparative study of the effects of gestodene 60 microg/ethinylestradiol 15 microg and desogestrel 150 microg/ethinylestradiol 20 microg on hemostatic balance, blood lipid levels and carbohydrate metabolism. Eur J Contracept Reprod Health Care. 1999;4 Suppl 2:27-35.
van der Mooren, M. J., Klipping, C., van Aken, B., Helmerhorst, E., Spielmann, D., & Kluft, C. (1999). A comparative study of the effects of gestodene 60 microg/ethinylestradiol 15 microg and desogestrel 150 microg/ethinylestradiol 20 microg on hemostatic balance, blood lipid levels and carbohydrate metabolism. The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, 4 Suppl 2, 27-35.
van der Mooren MJ, et al. A Comparative Study of the Effects of Gestodene 60 Microg/ethinylestradiol 15 Microg and Desogestrel 150 Microg/ethinylestradiol 20 Microg On Hemostatic Balance, Blood Lipid Levels and Carbohydrate Metabolism. Eur J Contracept Reprod Health Care. 1999;4 Suppl 2:27-35. PubMed PMID: 14677622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of the effects of gestodene 60 microg/ethinylestradiol 15 microg and desogestrel 150 microg/ethinylestradiol 20 microg on hemostatic balance, blood lipid levels and carbohydrate metabolism. AU - van der Mooren,M J, AU - Klipping,C, AU - van Aken,B, AU - Helmerhorst,E, AU - Spielmann,D, AU - Kluft,C, PY - 2003/12/18/pubmed PY - 2004/1/22/medline PY - 2003/12/18/entrez SP - 27 EP - 35 JF - The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception JO - Eur J Contracept Reprod Health Care VL - 4 Suppl 2 N2 - OBJECTIVES: This multicenter, randomized, parallel-group, open-label study was conducted to compare the effects of gestodene (GTD) 60 microg/ethinylestradiol (EE) 15 microg and desogestrel (DSG) 150 microg/EE 20 microg (Mercilon) on selected metabolic measurements during six cycles in 124 healthy women. METHODS: GTD/EE subjects received a single pill once daily from days 1 to 24 of a 28-day cycle, followed by placebo pills daily for the last 4 days of the cycle. DSG/EE subjects received a single pill daily from days 1 to 21 of a 28-day cycle, followed by a 7-day pill-free interval. Safety was assessed from changes in hemostatic measurements, lipid profile, glucose tolerance and adverse events. RESULTS: Both GTD/EE and DSG/EE groups exhibited minimal effects on the lipid profile. An increased glucose response was noted with both treatments and an increased insulin response was noted with GTD/EE. Hemostatic activity was increased in both groups but a counteracting increase in fibrinolytic activity occurred together with an increase in coagulatory activity. The incidence of adverse events was comparable between groups, and no significant differences in cycle control were observed between groups. No pregnancies occurred in either group. CONCLUSIONS: The 24-day GTD 60 microg/EE 15 microg formulation and DSG/EE produced similar effects on hemostatic balance, lipid metabolism and glucose tolerance, and exhibited comparable efficacy and tolerability. SN - 1362-5187 UR - https://www.unboundmedicine.com/medline/citation/14677622/A_comparative_study_of_the_effects_of_gestodene_60_microg/ethinylestradiol_15_microg_and_desogestrel_150_microg/ethinylestradiol_20_microg_on_hemostatic_balance_blood_lipid_levels_and_carbohydrate_metabolism_ L2 - http://www.tandfonline.com/doi/full/10.3109/13625189909085267 DB - PRIME DP - Unbound Medicine ER -