Tags

Type your tag names separated by a space and hit enter

Placental vascular endothelial growth factor receptor system mRNA expression in pigs selected for placental efficiency.
J Physiol. 2004 Jan 01; 554(Pt 1):194-201.JP

Abstract

Selecting Yorkshire breeding stock for increased placental efficiency (PE; piglet weight divided by its placental weight) results in larger litters (i.e. approximately 3 more piglets litter-1) and reduced placental sizes. Placental vessel density increases progressively after day 50 of gestation in the pig, and is positively correlated with PE and placental expression of vascular endothelial growth factor (VEGF), a potent angiogenic and permeability factor. To elicit its vascular effects, VEGF must bind to its receptors (R), VEGF-R1 and VEGF-R2. The objective of this study was to compare placental and endometrial blood vessel density and placental VEGF, VEGF-R1 and VEGF-R2 mRNA expression in day 70 and 90 conceptuses from Yorkshire females selected for high PE, low PE, and from unselected controls. A greater (P < 0.05) PE was observed for conceptuses in the high PE selection group when compared to the low PE selection group. Placental blood vessel density increased (P < 0.05) from day 70 to 90 (1.8 +/- 0.1 versus 2.8 +/- 0.2) in association with increases (P < 0.05) in placental VEGF mRNA expression. No selection group differences were observed in expression of VEGF, VEGF-R1, or VEGF-R2 on day 70. By day 90, however, placentae of conceptuses from the high PE group expressed greater (P < 0.05) amounts of VEGF and VEGF-R1 mRNA than the unselected controls and the low PE group. These data demonstrate that increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig. Although placental blood vessel density was not increased in the high PE selection group, elevated levels of the VEGF receptor system suggest an effect on increasing placental and endometrial blood vessel permeability and/or proximity in the high PE group.

Authors+Show Affiliations

Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14678501

Citation

Vonnahme, Kimberly A., and Stephen P. Ford. "Placental Vascular Endothelial Growth Factor Receptor System mRNA Expression in Pigs Selected for Placental Efficiency." The Journal of Physiology, vol. 554, no. Pt 1, 2004, pp. 194-201.
Vonnahme KA, Ford SP. Placental vascular endothelial growth factor receptor system mRNA expression in pigs selected for placental efficiency. J Physiol. 2004;554(Pt 1):194-201.
Vonnahme, K. A., & Ford, S. P. (2004). Placental vascular endothelial growth factor receptor system mRNA expression in pigs selected for placental efficiency. The Journal of Physiology, 554(Pt 1), 194-201.
Vonnahme KA, Ford SP. Placental Vascular Endothelial Growth Factor Receptor System mRNA Expression in Pigs Selected for Placental Efficiency. J Physiol. 2004 Jan 1;554(Pt 1):194-201. PubMed PMID: 14678501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental vascular endothelial growth factor receptor system mRNA expression in pigs selected for placental efficiency. AU - Vonnahme,Kimberly A, AU - Ford,Stephen P, PY - 2003/12/18/pubmed PY - 2004/4/7/medline PY - 2003/12/18/entrez SP - 194 EP - 201 JF - The Journal of physiology JO - J Physiol VL - 554 IS - Pt 1 N2 - Selecting Yorkshire breeding stock for increased placental efficiency (PE; piglet weight divided by its placental weight) results in larger litters (i.e. approximately 3 more piglets litter-1) and reduced placental sizes. Placental vessel density increases progressively after day 50 of gestation in the pig, and is positively correlated with PE and placental expression of vascular endothelial growth factor (VEGF), a potent angiogenic and permeability factor. To elicit its vascular effects, VEGF must bind to its receptors (R), VEGF-R1 and VEGF-R2. The objective of this study was to compare placental and endometrial blood vessel density and placental VEGF, VEGF-R1 and VEGF-R2 mRNA expression in day 70 and 90 conceptuses from Yorkshire females selected for high PE, low PE, and from unselected controls. A greater (P < 0.05) PE was observed for conceptuses in the high PE selection group when compared to the low PE selection group. Placental blood vessel density increased (P < 0.05) from day 70 to 90 (1.8 +/- 0.1 versus 2.8 +/- 0.2) in association with increases (P < 0.05) in placental VEGF mRNA expression. No selection group differences were observed in expression of VEGF, VEGF-R1, or VEGF-R2 on day 70. By day 90, however, placentae of conceptuses from the high PE group expressed greater (P < 0.05) amounts of VEGF and VEGF-R1 mRNA than the unselected controls and the low PE group. These data demonstrate that increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig. Although placental blood vessel density was not increased in the high PE selection group, elevated levels of the VEGF receptor system suggest an effect on increasing placental and endometrial blood vessel permeability and/or proximity in the high PE group. SN - 0022-3751 UR - https://www.unboundmedicine.com/medline/citation/14678501/Placental_vascular_endothelial_growth_factor_receptor_system_mRNA_expression_in_pigs_selected_for_placental_efficiency_ L2 - https://doi.org/10.1113/jphysiol.2003.055061 DB - PRIME DP - Unbound Medicine ER -