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Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women.
Bone. 2003 Dec; 33(6):956-9.BONE

Abstract

Genetic hyperhomocysteinemia is associated with skeletal abnormalities and osteoporosis. We tested whether levels of homocysteine and critical co-enzymes of homocysteine metabolism, such as vitamin B12 and folate, are related to lumbar spine bone mineral density (BMD) measured by DEXA in 161 postmenopausal women. Folate but not homocysteine or vitamin B12, was lower in osteoporotic than normal women (7.2 +/- 0.9 ng/L vs 11.4 +/- 0.7 ng/L, P < 0.003). Folate, but not homocysteine or vitamin B12, was independently related to BMD (r = 0.254, P < 0.011). BMD progressively increased from the lowest to the highest folate quartile (1.025 +/- 0.03 g/cm2 vs 1.15 +/- 0.03 g/cm2, P < 0.01) even when covaried for weight, which was the only other variable related to BMD. The present data suggest a major association between folate and bone mineralization.

Authors+Show Affiliations

Department of Obstetrics Gynecology and Pediatrics, Obstetrics and Gynecology, Policlinico of Modena, Modena, Italy. cagnacci@unimore.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14678855

Citation

Cagnacci, Angelo, et al. "Relation of Homocysteine, Folate, and Vitamin B12 to Bone Mineral Density of Postmenopausal Women." Bone, vol. 33, no. 6, 2003, pp. 956-9.
Cagnacci A, Baldassari F, Rivolta G, et al. Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone. 2003;33(6):956-9.
Cagnacci, A., Baldassari, F., Rivolta, G., Arangino, S., & Volpe, A. (2003). Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. Bone, 33(6), 956-9.
Cagnacci A, et al. Relation of Homocysteine, Folate, and Vitamin B12 to Bone Mineral Density of Postmenopausal Women. Bone. 2003;33(6):956-9. PubMed PMID: 14678855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of homocysteine, folate, and vitamin B12 to bone mineral density of postmenopausal women. AU - Cagnacci,Angelo, AU - Baldassari,Francesco, AU - Rivolta,Giovanni, AU - Arangino,Serenella, AU - Volpe,Annibale, PY - 2003/12/18/pubmed PY - 2004/9/1/medline PY - 2003/12/18/entrez SP - 956 EP - 9 JF - Bone JO - Bone VL - 33 IS - 6 N2 - Genetic hyperhomocysteinemia is associated with skeletal abnormalities and osteoporosis. We tested whether levels of homocysteine and critical co-enzymes of homocysteine metabolism, such as vitamin B12 and folate, are related to lumbar spine bone mineral density (BMD) measured by DEXA in 161 postmenopausal women. Folate but not homocysteine or vitamin B12, was lower in osteoporotic than normal women (7.2 +/- 0.9 ng/L vs 11.4 +/- 0.7 ng/L, P < 0.003). Folate, but not homocysteine or vitamin B12, was independently related to BMD (r = 0.254, P < 0.011). BMD progressively increased from the lowest to the highest folate quartile (1.025 +/- 0.03 g/cm2 vs 1.15 +/- 0.03 g/cm2, P < 0.01) even when covaried for weight, which was the only other variable related to BMD. The present data suggest a major association between folate and bone mineralization. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/14678855/Relation_of_homocysteine_folate_and_vitamin_B12_to_bone_mineral_density_of_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756328203002692 DB - PRIME DP - Unbound Medicine ER -