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Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.
Cancer Res. 2003 Dec 01; 63(23):8118-21.CR

Abstract

Epidemiological data and in vitro studies on cancer chemoprevention by tea polyphenols have gained attention recently from the scientific community, nutritionists, the pharmaceutical industry, and the public. Despite the several efforts made recently to elucidate the molecular basis for the anticancer activity of these natural products, little correlation has been found thus far between the putative protein targets of compounds found in tea extracts and levels found in plasma after tea consumption. Here, by using a combination of nuclear magnetic resonance binding assays, fluorescence polarization assay, and computational docking studies, we found that certain green tea catechins and black tea theaflavins are very potent inhibitors (K(i) in the nanomolar range) of the antiapoptotic Bcl-2-family proteins, Bcl-x(L) and Bcl-2. These data suggest a strong link between the anticancer activities of these tea polyphenols and their inhibition of a crucial antiapoptotic pathway, which is implicated in the development of many human malignancies.

Authors+Show Affiliations

The Burnham Institute, La Jolla, California 92037, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14678963

Citation

Leone, Marilisa, et al. "Cancer Prevention By Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-family Proteins." Cancer Research, vol. 63, no. 23, 2003, pp. 8118-21.
Leone M, Zhai D, Sareth S, et al. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Res. 2003;63(23):8118-21.
Leone, M., Zhai, D., Sareth, S., Kitada, S., Reed, J. C., & Pellecchia, M. (2003). Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Research, 63(23), 8118-21.
Leone M, et al. Cancer Prevention By Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-family Proteins. Cancer Res. 2003 Dec 1;63(23):8118-21. PubMed PMID: 14678963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. AU - Leone,Marilisa, AU - Zhai,Dayong, AU - Sareth,Sina, AU - Kitada,Shinichi, AU - Reed,John C, AU - Pellecchia,Maurizio, PY - 2003/12/18/pubmed PY - 2004/2/28/medline PY - 2003/12/18/entrez SP - 8118 EP - 21 JF - Cancer research JO - Cancer Res VL - 63 IS - 23 N2 - Epidemiological data and in vitro studies on cancer chemoprevention by tea polyphenols have gained attention recently from the scientific community, nutritionists, the pharmaceutical industry, and the public. Despite the several efforts made recently to elucidate the molecular basis for the anticancer activity of these natural products, little correlation has been found thus far between the putative protein targets of compounds found in tea extracts and levels found in plasma after tea consumption. Here, by using a combination of nuclear magnetic resonance binding assays, fluorescence polarization assay, and computational docking studies, we found that certain green tea catechins and black tea theaflavins are very potent inhibitors (K(i) in the nanomolar range) of the antiapoptotic Bcl-2-family proteins, Bcl-x(L) and Bcl-2. These data suggest a strong link between the anticancer activities of these tea polyphenols and their inhibition of a crucial antiapoptotic pathway, which is implicated in the development of many human malignancies. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/14678963/Cancer_prevention_by_tea_polyphenols_is_linked_to_their_direct_inhibition_of_antiapoptotic_Bcl_2_family_proteins_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14678963 DB - PRIME DP - Unbound Medicine ER -