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Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men.
Eur J Clin Nutr. 2004 Jan; 58(1):40-5.EJ

Abstract

OBJECTIVE

To investigate whether the daily intake of red wine (RW) at a dose which inversely correlates with cardiovascular disease (CVD) risk modulates immune functions in healthy men.

DESIGN

Randomized single-blind trial with four intervention periods.

SETTING

The Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany.

SUBJECTS

A total of 24 healthy males with moderate alcohol consumption patterns were recruited and all completed the study.

INTERVENTION

Participants consumed 500 ml of RW (12% ethanol (ETOH)) or 500 ml of a 12% ETOH dilution per day for a period of 2 weeks. To control the potential effects of RW polyphenols, accordingly 500 ml/day of dealcoholized red wine (DRW) and of red grape juice (RGJ) were given. The following immune parameters were measured before beverage consumption and at 1 and 2 weeks following beverage consumption: phagocytic activity of neutrophils and monocytes, production of tumor necrosis factor-alpha (TNFalpha), interleukin-2 and -4, transforming growth factor-beta, TNFalpha mRNA, lymphocyte proliferation, lytic activity of natural killer cells, and percentage of apoptotic lymphocytes.

RESULTS

Consumption of a moderate volume of alcohol with RW and with a 12% ETOH dilution had no effect on immune functions in healthy males. Consumption of polyphenol-rich beverages (DRW and RGJ) did not affect immunity-related parameters.

CONCLUSIONS

Daily moderate consumption of alcohol and of RW for 2 weeks at doses which inversely correlate with CVD risk has no adverse effects on human immune cell functions. Polyphenol-rich beverages such as RGJ and DRW further do not suppress immune responses in healthy men.

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Authors+Show Affiliations

Watzl B
Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany. bernhard.watzl@bfe.uni-karlsruhe.de
Bub A
No affiliation info available
Pretzer G
No affiliation info available
Roser S
No affiliation info available
Barth SW
No affiliation info available
Rechkemmer G
No affiliation info available

MeSH

AdultAlcohol DrinkingCross-Over StudiesCytokinesFlavonoidsHumansImmunity, CellularLymphocyte ActivationMalePhagocytosisPhenolsPolyphenolsSingle-Blind MethodWine

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14679365

Citation

Watzl, B, et al. "Daily Moderate Amounts of Red Wine or Alcohol Have No Effect On the Immune System of Healthy Men." European Journal of Clinical Nutrition, vol. 58, no. 1, 2004, pp. 40-5.
Watzl B, Bub A, Pretzer G, et al. Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men. Eur J Clin Nutr. 2004;58(1):40-5.
Watzl, B., Bub, A., Pretzer, G., Roser, S., Barth, S. W., & Rechkemmer, G. (2004). Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men. European Journal of Clinical Nutrition, 58(1), 40-5.
Watzl B, et al. Daily Moderate Amounts of Red Wine or Alcohol Have No Effect On the Immune System of Healthy Men. Eur J Clin Nutr. 2004;58(1):40-5. PubMed PMID: 14679365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men. AU - Watzl,B, AU - Bub,A, AU - Pretzer,G, AU - Roser,S, AU - Barth,S W, AU - Rechkemmer,G, PY - 2003/12/18/pubmed PY - 2004/6/4/medline PY - 2003/12/18/entrez SP - 40 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 1 N2 - OBJECTIVE: To investigate whether the daily intake of red wine (RW) at a dose which inversely correlates with cardiovascular disease (CVD) risk modulates immune functions in healthy men. DESIGN: Randomized single-blind trial with four intervention periods. SETTING: The Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany. SUBJECTS: A total of 24 healthy males with moderate alcohol consumption patterns were recruited and all completed the study. INTERVENTION: Participants consumed 500 ml of RW (12% ethanol (ETOH)) or 500 ml of a 12% ETOH dilution per day for a period of 2 weeks. To control the potential effects of RW polyphenols, accordingly 500 ml/day of dealcoholized red wine (DRW) and of red grape juice (RGJ) were given. The following immune parameters were measured before beverage consumption and at 1 and 2 weeks following beverage consumption: phagocytic activity of neutrophils and monocytes, production of tumor necrosis factor-alpha (TNFalpha), interleukin-2 and -4, transforming growth factor-beta, TNFalpha mRNA, lymphocyte proliferation, lytic activity of natural killer cells, and percentage of apoptotic lymphocytes. RESULTS: Consumption of a moderate volume of alcohol with RW and with a 12% ETOH dilution had no effect on immune functions in healthy males. Consumption of polyphenol-rich beverages (DRW and RGJ) did not affect immunity-related parameters. CONCLUSIONS: Daily moderate consumption of alcohol and of RW for 2 weeks at doses which inversely correlate with CVD risk has no adverse effects on human immune cell functions. Polyphenol-rich beverages such as RGJ and DRW further do not suppress immune responses in healthy men. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/14679365/Daily_moderate_amounts_of_red_wine_or_alcohol_have_no_effect_on_the_immune_system_of_healthy_men_ L2 - https://doi.org/10.1038/sj.ejcn.1601742 DB - PRIME DP - Unbound Medicine ER -