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Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study.
Eur J Clin Nutr 2004; 58(1):173-9EJ

Abstract

BACKGROUND

Isoflavones are estrogen-like plant compounds that may protect against cardiovascular disease and endocrine-responsive cancer. Isoflavones may, because of their ability to act as selective estrogen receptor modulators, alter insulin-like growth factor (IGF) status.

OBJECTIVE

The aim of this study was to assess the effect of 1-month isoflavone supplementation (86 mg/day red clover-derived isoflavones) on IGF status.

DESIGN AND SUBJECTS

Healthy pre- (n=16) and postmenopausal (n=7) women were invited to take part in a randomised, placebo-controlled crossover study with a minimum 2-month washout period.

RESULTS

: For premenopausal subjects, the change in IGF-1, IGF-BP1 and IGF-BP3 assessed at different points of the menstrual cycle did not differ between isoflavone and placebo phase. However, the change in IGF-1, when examined pre- and post-supplementation, was nonsignificantly reduced (P=0.06) on the isoflavone supplement compared to placebo. For postmenopausal subjects, the change in IGF-1, IGF-BP1 and IGFBP-3 concentrations over the supplementation period did not differ between isoflavone or placebo phase. Isoflavones increased HDL in postmenopausal women compared to placebo (P=0.02) but did not alter either cholesterol or triacylglycerol concentrations, and had no effect on antioxidant status.

CONCLUSIONS

This study shows that 1-month supplementation with red clover isoflavones has a positive effect on HDL cholesterol, but at most a small effect on IGF status in premenopausal and no effect in postmenopausal subjects. Further studies are required to ascertain the role these dietary compounds may have to play in breast cancer prevention.

Authors+Show Affiliations

Department of Surgery, Royal Free and University College London Medical School, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14679383

Citation

Campbell, M J., et al. "Effect of Red Clover-derived Isoflavone Supplementation On Insulin-like Growth Factor, Lipid and Antioxidant Status in Healthy Female Volunteers: a Pilot Study." European Journal of Clinical Nutrition, vol. 58, no. 1, 2004, pp. 173-9.
Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr. 2004;58(1):173-9.
Campbell, M. J., Woodside, J. V., Honour, J. W., Morton, M. S., & Leathem, A. J. (2004). Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. European Journal of Clinical Nutrition, 58(1), pp. 173-9.
Campbell MJ, et al. Effect of Red Clover-derived Isoflavone Supplementation On Insulin-like Growth Factor, Lipid and Antioxidant Status in Healthy Female Volunteers: a Pilot Study. Eur J Clin Nutr. 2004;58(1):173-9. PubMed PMID: 14679383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. AU - Campbell,M J, AU - Woodside,J V, AU - Honour,J W, AU - Morton,M S, AU - Leathem,A J C, PY - 2003/12/18/pubmed PY - 2004/6/4/medline PY - 2003/12/18/entrez SP - 173 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 58 IS - 1 N2 - BACKGROUND: Isoflavones are estrogen-like plant compounds that may protect against cardiovascular disease and endocrine-responsive cancer. Isoflavones may, because of their ability to act as selective estrogen receptor modulators, alter insulin-like growth factor (IGF) status. OBJECTIVE: The aim of this study was to assess the effect of 1-month isoflavone supplementation (86 mg/day red clover-derived isoflavones) on IGF status. DESIGN AND SUBJECTS: Healthy pre- (n=16) and postmenopausal (n=7) women were invited to take part in a randomised, placebo-controlled crossover study with a minimum 2-month washout period. RESULTS: : For premenopausal subjects, the change in IGF-1, IGF-BP1 and IGF-BP3 assessed at different points of the menstrual cycle did not differ between isoflavone and placebo phase. However, the change in IGF-1, when examined pre- and post-supplementation, was nonsignificantly reduced (P=0.06) on the isoflavone supplement compared to placebo. For postmenopausal subjects, the change in IGF-1, IGF-BP1 and IGFBP-3 concentrations over the supplementation period did not differ between isoflavone or placebo phase. Isoflavones increased HDL in postmenopausal women compared to placebo (P=0.02) but did not alter either cholesterol or triacylglycerol concentrations, and had no effect on antioxidant status. CONCLUSIONS: This study shows that 1-month supplementation with red clover isoflavones has a positive effect on HDL cholesterol, but at most a small effect on IGF status in premenopausal and no effect in postmenopausal subjects. Further studies are required to ascertain the role these dietary compounds may have to play in breast cancer prevention. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/14679383/Effect_of_red_clover_derived_isoflavone_supplementation_on_insulin_like_growth_factor_lipid_and_antioxidant_status_in_healthy_female_volunteers:_a_pilot_study_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601764 DB - PRIME DP - Unbound Medicine ER -