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Incidence and predictors of severe liver fibrosis in human immunodeficiency virus-infected patients with chronic hepatitis C: a European collaborative study.
Clin Infect Dis. 2004 Jan 01; 38(1):128-33.CI

Abstract

A study was performed in 10 European health care centers in which 914 patients coinfected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) who had elevated serum alanine aminotransferase (ALT) levels underwent liver biopsy during the period of 1992 through 2002. Overall, the METAVIR liver fibrosis stage was F0 in 10% of patients, F1 in 33%, F2 in 22%, F3 in 22%, and F4 in 13%. Predictors of severe liver fibrosis (METAVIR stage, F3 or F4) in multivariate analysis were age of >35 years (odds ratio [OR], 2.95; 95% confidence interval [CI], 2.08-4.18), alcohol consumption of >50 g/day (OR, 1.61; 95% CI, 1.1-2.35), and CD4+ T cell count of <500 cells/mm3 (OR, 1.43; 95% CI, 1.03-1.98). Forty-six percent of patients aged >40 years had severe liver fibrosis, compared with 15% of subjects aged <30 years. The use of antiretroviral therapy was not associated with the severity of liver fibrosis. In summary, severe liver fibrosis is frequently found in HCV-HIV-coinfected patients with elevated serum ALT levels, and its severity increases significantly with age. The rate of complications due to end-stage liver disease will inevitably increase in this population, for whom anti-HCV therapy should be considered a priority.

Authors+Show Affiliations

Hospital Carlos III, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14679458

Citation

Martín-Carbonero, Luz, et al. "Incidence and Predictors of Severe Liver Fibrosis in Human Immunodeficiency Virus-infected Patients With Chronic Hepatitis C: a European Collaborative Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 38, no. 1, 2004, pp. 128-33.
Martín-Carbonero L, Benhamou Y, Puoti M, et al. Incidence and predictors of severe liver fibrosis in human immunodeficiency virus-infected patients with chronic hepatitis C: a European collaborative study. Clin Infect Dis. 2004;38(1):128-33.
Martín-Carbonero, L., Benhamou, Y., Puoti, M., Berenguer, J., Mallolas, J., Quereda, C., Arizcorreta, A., Gonzalez, A., Rockstroh, J., Asensi, V., Miralles, P., Laguno, M., Moreno, L., Girón, J. A., Vogel, M., García-Samaniego, J., Nuñez, M., Romero, M., Moreno, S., ... Soriano, V. (2004). Incidence and predictors of severe liver fibrosis in human immunodeficiency virus-infected patients with chronic hepatitis C: a European collaborative study. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 38(1), 128-33.
Martín-Carbonero L, et al. Incidence and Predictors of Severe Liver Fibrosis in Human Immunodeficiency Virus-infected Patients With Chronic Hepatitis C: a European Collaborative Study. Clin Infect Dis. 2004 Jan 1;38(1):128-33. PubMed PMID: 14679458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and predictors of severe liver fibrosis in human immunodeficiency virus-infected patients with chronic hepatitis C: a European collaborative study. AU - Martín-Carbonero,Luz, AU - Benhamou,Yves, AU - Puoti,Massimo, AU - Berenguer,Juan, AU - Mallolas,José, AU - Quereda,Carmen, AU - Arizcorreta,Ana, AU - Gonzalez,Antonio, AU - Rockstroh,Jurgen, AU - Asensi,Victor, AU - Miralles,Pilar, AU - Laguno,Montse, AU - Moreno,Leonor, AU - Girón,José Antonio, AU - Vogel,Martin, AU - García-Samaniego,Javier, AU - Nuñez,Marina, AU - Romero,Miriam, AU - Moreno,Santiago, AU - de la Cruz,Juan José, AU - Soriano,Vincent, Y1 - 2003/12/08/ PY - 2003/07/24/received PY - 2003/08/27/accepted PY - 2003/12/18/pubmed PY - 2004/2/24/medline PY - 2003/12/18/entrez SP - 128 EP - 33 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 38 IS - 1 N2 - A study was performed in 10 European health care centers in which 914 patients coinfected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) who had elevated serum alanine aminotransferase (ALT) levels underwent liver biopsy during the period of 1992 through 2002. Overall, the METAVIR liver fibrosis stage was F0 in 10% of patients, F1 in 33%, F2 in 22%, F3 in 22%, and F4 in 13%. Predictors of severe liver fibrosis (METAVIR stage, F3 or F4) in multivariate analysis were age of >35 years (odds ratio [OR], 2.95; 95% confidence interval [CI], 2.08-4.18), alcohol consumption of >50 g/day (OR, 1.61; 95% CI, 1.1-2.35), and CD4+ T cell count of <500 cells/mm3 (OR, 1.43; 95% CI, 1.03-1.98). Forty-six percent of patients aged >40 years had severe liver fibrosis, compared with 15% of subjects aged <30 years. The use of antiretroviral therapy was not associated with the severity of liver fibrosis. In summary, severe liver fibrosis is frequently found in HCV-HIV-coinfected patients with elevated serum ALT levels, and its severity increases significantly with age. The rate of complications due to end-stage liver disease will inevitably increase in this population, for whom anti-HCV therapy should be considered a priority. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/14679458/Incidence_and_predictors_of_severe_liver_fibrosis_in_human_immunodeficiency_virus_infected_patients_with_chronic_hepatitis_C:_a_European_collaborative_study_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/380130 DB - PRIME DP - Unbound Medicine ER -