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[The beneficial effect of genistein on mandible bone metabolism in ovariectomized rats].
Zhonghua Kou Qiang Yi Xue Za Zhi. 2003 Sep; 38(5):336-8.ZK

Abstract

OBJECTIVE

To detect the effect of genistein on mandible metabolism in ovariectomized rats.

METHODS

Forty 12 week-old female SD rats were randomly assigned to four groups: (1) sham operated; (2) ovariectomized; (3) ovariectomized and treated with estradiol; (4) ovariectomized and received genistein, 45 mg/kg body weight per day. After 12 weeks, bone mineral density (BMD), serum level of alkaline phosphatase (ALP), acid phosphatase (ACP), osteocalcin, IL-1beta, TNF-alpha, IL-6 and calcitonin (CT) were evaluated. In addition, the serum estradiol and the weight of uteri were also examined to indicate the side effect of genistein to the uteri.

RESULTS

Ovariectomized animals had a significant decrease in BMD, and increased serum level of ALP, ACP, IL-1beta and osteocalcin compared with sham rats. After treated with genistein, BMD and the serum level of ALP, ACP, osteocalcin increased significantly, while the serum level of IL-1beta and TNF-alpha decreased. Especially, the increase of ALP and osteocalcin was higher than that of estradiol-treated animal. Additionally, the uterus weight index and the serum estradiol in genistein-treated rats were lower significantly than those of estradiol-treated rats.

CONCLUSIONS

Genistein can improve the mandible bone metabolism as well as its effect on femur through the promotion of bone formation and the prevention of bone resorption with slight side effect. Genistein provides an additional viable way to therapy for osteoporosis in the jaw bones.

Authors+Show Affiliations

Department of Oral Pathology, Peking University School of Stomatology, Beijing 100081, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14680578

Citation

Li, Bin-bin, et al. "[The Beneficial Effect of Genistein On Mandible Bone Metabolism in Ovariectomized Rats]." Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, vol. 38, no. 5, 2003, pp. 336-8.
Li BB, Yu SF, Meng XM. [The beneficial effect of genistein on mandible bone metabolism in ovariectomized rats]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2003;38(5):336-8.
Li, B. B., Yu, S. F., & Meng, X. M. (2003). [The beneficial effect of genistein on mandible bone metabolism in ovariectomized rats]. Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology, 38(5), 336-8.
Li BB, Yu SF, Meng XM. [The Beneficial Effect of Genistein On Mandible Bone Metabolism in Ovariectomized Rats]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2003;38(5):336-8. PubMed PMID: 14680578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The beneficial effect of genistein on mandible bone metabolism in ovariectomized rats]. AU - Li,Bin-bin, AU - Yu,Shi-feng, AU - Meng,Xue-mei, PY - 2003/12/19/pubmed PY - 2004/2/27/medline PY - 2003/12/19/entrez SP - 336 EP - 8 JF - Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology JO - Zhonghua Kou Qiang Yi Xue Za Zhi VL - 38 IS - 5 N2 - OBJECTIVE: To detect the effect of genistein on mandible metabolism in ovariectomized rats. METHODS: Forty 12 week-old female SD rats were randomly assigned to four groups: (1) sham operated; (2) ovariectomized; (3) ovariectomized and treated with estradiol; (4) ovariectomized and received genistein, 45 mg/kg body weight per day. After 12 weeks, bone mineral density (BMD), serum level of alkaline phosphatase (ALP), acid phosphatase (ACP), osteocalcin, IL-1beta, TNF-alpha, IL-6 and calcitonin (CT) were evaluated. In addition, the serum estradiol and the weight of uteri were also examined to indicate the side effect of genistein to the uteri. RESULTS: Ovariectomized animals had a significant decrease in BMD, and increased serum level of ALP, ACP, IL-1beta and osteocalcin compared with sham rats. After treated with genistein, BMD and the serum level of ALP, ACP, osteocalcin increased significantly, while the serum level of IL-1beta and TNF-alpha decreased. Especially, the increase of ALP and osteocalcin was higher than that of estradiol-treated animal. Additionally, the uterus weight index and the serum estradiol in genistein-treated rats were lower significantly than those of estradiol-treated rats. CONCLUSIONS: Genistein can improve the mandible bone metabolism as well as its effect on femur through the promotion of bone formation and the prevention of bone resorption with slight side effect. Genistein provides an additional viable way to therapy for osteoporosis in the jaw bones. SN - 1002-0098 UR - https://www.unboundmedicine.com/medline/citation/14680578/[The_beneficial_effect_of_genistein_on_mandible_bone_metabolism_in_ovariectomized_rats]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1002-0098&year=2003&vol=38&issue=5&fpage=336 DB - PRIME DP - Unbound Medicine ER -