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MEROPS: the peptidase database.
Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D160-4.NA

Abstract

Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added.

Authors+Show Affiliations

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. ndr@sanger.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14681384

Citation

Rawlings, Neil D., et al. "MEROPS: the Peptidase Database." Nucleic Acids Research, vol. 32, no. Database issue, 2004, pp. D160-4.
Rawlings ND, Tolle DP, Barrett AJ. MEROPS: the peptidase database. Nucleic Acids Res. 2004;32(Database issue):D160-4.
Rawlings, N. D., Tolle, D. P., & Barrett, A. J. (2004). MEROPS: the peptidase database. Nucleic Acids Research, 32(Database issue), D160-4.
Rawlings ND, Tolle DP, Barrett AJ. MEROPS: the Peptidase Database. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D160-4. PubMed PMID: 14681384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MEROPS: the peptidase database. AU - Rawlings,Neil D, AU - Tolle,Dominic P, AU - Barrett,Alan J, PY - 2003/12/19/pubmed PY - 2004/1/21/medline PY - 2003/12/19/entrez SP - D160 EP - 4 JF - Nucleic acids research JO - Nucleic Acids Res VL - 32 IS - Database issue N2 - Peptidases (proteolytic enzymes) are of great relevance to biology, medicine and biotechnology. This practical importance creates a need for an integrated source of information about them, and also about their natural inhibitors. The MEROPS database (http://merops.sanger.ac.uk) aims to fill this need. The organizational principle of the database is a hierarchical classification in which homologous sets of the proteins of interest are grouped in families and the homologous families are grouped in clans. Each peptidase, family and clan has a unique identifier. The database has recently been expanded to include the protein inhibitors of peptidases, and these are classified in much the same way as the peptidases. Forms of information recently added include new links to other databases, summary alignments for peptidase clans, displays to show the distribution of peptidases and inhibitors among organisms, substrate cleavage sites and indexes for expressed sequence tag libraries containing peptidases. A new way of making hyperlinks to the database has been devised and a BlastP search of our library of peptidase and inhibitor sequences has been added. SN - 1362-4962 UR - https://www.unboundmedicine.com/medline/citation/14681384/MEROPS:_the_peptidase_database_ L2 - https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkh071 DB - PRIME DP - Unbound Medicine ER -