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Metabolic effects of dietary fructose in diabetic subjects.
Diabetes Care 1992; 15(11):1468-76DC

Abstract

OBJECTIVE

To assess the metabolic effects of chronic dietary fructose consumption in diabetic subjects.

RESEARCH DESIGN AND METHODS

Six type I and 12 type II diabetic subjects consumed, in random order, two isocaloric study diets for 28 days. In one diet, 20% of energy was derived from fructose. In the other diet, < 3% of energy came from fructose, and carbohydrate energy was derived primarily from starch. Both study diets were composed of common foods. All meals were prepared in a metabolic kitchen where all foods were weighed during meal preparation.

RESULTS

Mean plasma glucose, urine glucose, and serum glycosylated albumin values were lower during the fructose diet than during the starch diet, but the differences achieved only marginal statistical significance. The day-28 value for mean plasma glucose was 12.5% lower (P = 0.03) during the fructose diet than during the starch diet. At days 14, 21, and 28, fasting serum cholesterol and LDL cholesterol were both significantly higher during the fructose diet than during the starch diet. The day-28 values for serum cholesterol and LDL cholesterol during the fructose diet were 6.9% (P = 0.008) and 10.9% (P = 0.002) higher, respectively, than the corresponding values during the starch diet. No differences were observed between the study diets in fasting serum HDL cholesterol, fasting serum triglycerides, peak postprandial serum triglycerides, or fasting serum lactate. Peak postprandial serum lactate was significantly higher during the fructose diet. Type I and type II diabetic subjects responded to the diets in a consistent way, but type I subjects experienced significantly more hypoglycemia during the fructose diet than during the starch diet.

CONCLUSIONS

A high-fructose diet may result in reduced glycemia in diabetic subjects but at the expense of increased fasting serum total and LDL cholesterol.

Authors+Show Affiliations

Department of Medicine, School of Public Health, University of Minnesota, Minneapolis 55455.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1468273

Citation

Bantle, J P., et al. "Metabolic Effects of Dietary Fructose in Diabetic Subjects." Diabetes Care, vol. 15, no. 11, 1992, pp. 1468-76.
Bantle JP, Swanson JE, Thomas W, et al. Metabolic effects of dietary fructose in diabetic subjects. Diabetes Care. 1992;15(11):1468-76.
Bantle, J. P., Swanson, J. E., Thomas, W., & Laine, D. C. (1992). Metabolic effects of dietary fructose in diabetic subjects. Diabetes Care, 15(11), pp. 1468-76.
Bantle JP, et al. Metabolic Effects of Dietary Fructose in Diabetic Subjects. Diabetes Care. 1992;15(11):1468-76. PubMed PMID: 1468273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic effects of dietary fructose in diabetic subjects. AU - Bantle,J P, AU - Swanson,J E, AU - Thomas,W, AU - Laine,D C, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 1468 EP - 76 JF - Diabetes care JO - Diabetes Care VL - 15 IS - 11 N2 - OBJECTIVE: To assess the metabolic effects of chronic dietary fructose consumption in diabetic subjects. RESEARCH DESIGN AND METHODS: Six type I and 12 type II diabetic subjects consumed, in random order, two isocaloric study diets for 28 days. In one diet, 20% of energy was derived from fructose. In the other diet, < 3% of energy came from fructose, and carbohydrate energy was derived primarily from starch. Both study diets were composed of common foods. All meals were prepared in a metabolic kitchen where all foods were weighed during meal preparation. RESULTS: Mean plasma glucose, urine glucose, and serum glycosylated albumin values were lower during the fructose diet than during the starch diet, but the differences achieved only marginal statistical significance. The day-28 value for mean plasma glucose was 12.5% lower (P = 0.03) during the fructose diet than during the starch diet. At days 14, 21, and 28, fasting serum cholesterol and LDL cholesterol were both significantly higher during the fructose diet than during the starch diet. The day-28 values for serum cholesterol and LDL cholesterol during the fructose diet were 6.9% (P = 0.008) and 10.9% (P = 0.002) higher, respectively, than the corresponding values during the starch diet. No differences were observed between the study diets in fasting serum HDL cholesterol, fasting serum triglycerides, peak postprandial serum triglycerides, or fasting serum lactate. Peak postprandial serum lactate was significantly higher during the fructose diet. Type I and type II diabetic subjects responded to the diets in a consistent way, but type I subjects experienced significantly more hypoglycemia during the fructose diet than during the starch diet. CONCLUSIONS: A high-fructose diet may result in reduced glycemia in diabetic subjects but at the expense of increased fasting serum total and LDL cholesterol. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/1468273/Metabolic_effects_of_dietary_fructose_in_diabetic_subjects_ L2 - https://medlineplus.gov/diabeticdiet.html DB - PRIME DP - Unbound Medicine ER -