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Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects.
Clin Sci (Lond). 2004 May; 106(5):519-25.CS

Abstract

Mediterranean-inspired diets have been shown to decrease cholesterol levels in patients with hypercholesterolaemia, who frequently exhibit endothelial dysfunction. The aims of the present study are to improve endothelial function by dietary intervention in healthy subjects with lipid levels representative of a Western population. Twenty-two healthy subjects (mean total cholesterol, 5.6 mmol/l) were given a Mediterranean-inspired diet rich in omega-3 fatty acids and sterol esters, but low in saturated fat, or an ordinary Swedish diet, for 4 weeks in a randomized cross-over study. The composition of the diets were: in the Swedish diet, 2090 kcal (where 1 kcal=4.184 kJ; 48% of energy from carbohydrate, 15% from protein and 36% from fat) and 19 g of fibre; in the Mediterranean-inspired diet, 1869 kcal (48% of energy from carbohydrate, 16% from protein, 34% from fat) and 40 g of fibre. After each dietary period, fasting blood lipids, insulin and glucose levels, as well as apo B (apolipoprotein B) and LDL (low-density lipoprotein) particle size, were analysed. Endothelial-dependent and -independent vasodilation was measured invasively by venous occlusion plethysmography, and arterial distensibility was assessed by echocardiography tracking. Fibrinolytic capacity across the forearm, as well as oxidative stress measured through urinary F(2)-isoprostane, were evaluated. Total, LDL- and apo B-cholesterol and triacylglycerol (triglyceride) concentrations were decreased by 17%, 22%, 16% and 17% respectively, after the Mediterranean-inspired diet compared with the Swedish diet (P <0.05 for all). However, no differences in plasma concentrations of insulin and glucose and LDL particle size, endothelial function, arterial distensibility, fibrinolytic capacity or oxidative stress were detected. Treatment for 4 weeks with a Mediterranean-inspired diet decreased blood lipids in healthy individuals with a low-risk profile for cardiovascular disease. This beneficial effect was not mirrored in vascular function or oxidative stress evaluation.

Authors+Show Affiliations

Department of Clinical Physiology, Sahlgrenska University Hospital, 41345 Göteborg, Sweden. anneli.ambring@klinfys.gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14683522

Citation

Ambring, Anneli, et al. "Effects of a Mediterranean-inspired Diet On Blood Lipids, Vascular Function and Oxidative Stress in Healthy Subjects." Clinical Science (London, England : 1979), vol. 106, no. 5, 2004, pp. 519-25.
Ambring A, Friberg P, Axelsen M, et al. Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects. Clin Sci (Lond). 2004;106(5):519-25.
Ambring, A., Friberg, P., Axelsen, M., Laffrenzen, M., Taskinen, M. R., Basu, S., & Johansson, M. (2004). Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects. Clinical Science (London, England : 1979), 106(5), 519-25.
Ambring A, et al. Effects of a Mediterranean-inspired Diet On Blood Lipids, Vascular Function and Oxidative Stress in Healthy Subjects. Clin Sci (Lond). 2004;106(5):519-25. PubMed PMID: 14683522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects. AU - Ambring,Anneli, AU - Friberg,Peter, AU - Axelsen,Mette, AU - Laffrenzen,Magdalena, AU - Taskinen,Marja-Riitta, AU - Basu,Samar, AU - Johansson,Mats, PY - 2003/12/19/accepted PY - 2003/12/15/revised PY - 2003/09/23/received PY - 2003/12/20/pubmed PY - 2004/6/23/medline PY - 2003/12/20/entrez SP - 519 EP - 25 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 106 IS - 5 N2 - Mediterranean-inspired diets have been shown to decrease cholesterol levels in patients with hypercholesterolaemia, who frequently exhibit endothelial dysfunction. The aims of the present study are to improve endothelial function by dietary intervention in healthy subjects with lipid levels representative of a Western population. Twenty-two healthy subjects (mean total cholesterol, 5.6 mmol/l) were given a Mediterranean-inspired diet rich in omega-3 fatty acids and sterol esters, but low in saturated fat, or an ordinary Swedish diet, for 4 weeks in a randomized cross-over study. The composition of the diets were: in the Swedish diet, 2090 kcal (where 1 kcal=4.184 kJ; 48% of energy from carbohydrate, 15% from protein and 36% from fat) and 19 g of fibre; in the Mediterranean-inspired diet, 1869 kcal (48% of energy from carbohydrate, 16% from protein, 34% from fat) and 40 g of fibre. After each dietary period, fasting blood lipids, insulin and glucose levels, as well as apo B (apolipoprotein B) and LDL (low-density lipoprotein) particle size, were analysed. Endothelial-dependent and -independent vasodilation was measured invasively by venous occlusion plethysmography, and arterial distensibility was assessed by echocardiography tracking. Fibrinolytic capacity across the forearm, as well as oxidative stress measured through urinary F(2)-isoprostane, were evaluated. Total, LDL- and apo B-cholesterol and triacylglycerol (triglyceride) concentrations were decreased by 17%, 22%, 16% and 17% respectively, after the Mediterranean-inspired diet compared with the Swedish diet (P <0.05 for all). However, no differences in plasma concentrations of insulin and glucose and LDL particle size, endothelial function, arterial distensibility, fibrinolytic capacity or oxidative stress were detected. Treatment for 4 weeks with a Mediterranean-inspired diet decreased blood lipids in healthy individuals with a low-risk profile for cardiovascular disease. This beneficial effect was not mirrored in vascular function or oxidative stress evaluation. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/14683522/Effects_of_a_Mediterranean_inspired_diet_on_blood_lipids_vascular_function_and_oxidative_stress_in_healthy_subjects_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20030315 DB - PRIME DP - Unbound Medicine ER -