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New orally active PDE4 inhibitors with therapeutic potential.
Bioorg Med Chem Lett 2004; 14(1):29-32BM

Abstract

Structural optimization of pyrazolopyridine derivative 2, which is one of the newly discovered chemical leads for PDE4 inhibitors from our in-house library, was carried out successfully. The process of discovery of new orally active PDE4 inhibitors, which are expected to possess therapeutic potential, is presented and their structure-activity relationships are discussed.

Authors+Show Affiliations

Minase Research Institute, Ono Pharmaceutical Co. Ltd, 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14684291

Citation

Ochiai, Hiroshi, et al. "New Orally Active PDE4 Inhibitors With Therapeutic Potential." Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 1, 2004, pp. 29-32.
Ochiai H, Ishida A, Ohtani T, et al. New orally active PDE4 inhibitors with therapeutic potential. Bioorg Med Chem Lett. 2004;14(1):29-32.
Ochiai, H., Ishida, A., Ohtani, T., Kusumi, K., Kishikawa, K., Obata, T., ... Toda, M. (2004). New orally active PDE4 inhibitors with therapeutic potential. Bioorganic & Medicinal Chemistry Letters, 14(1), pp. 29-32.
Ochiai H, et al. New Orally Active PDE4 Inhibitors With Therapeutic Potential. Bioorg Med Chem Lett. 2004 Jan 5;14(1):29-32. PubMed PMID: 14684291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New orally active PDE4 inhibitors with therapeutic potential. AU - Ochiai,Hiroshi, AU - Ishida,Akiharu, AU - Ohtani,Tazumi, AU - Kusumi,Kensuke, AU - Kishikawa,Katuya, AU - Obata,Takaaki, AU - Nakai,Hisao, AU - Toda,Masaaki, PY - 2003/12/20/pubmed PY - 2004/8/28/medline PY - 2003/12/20/entrez SP - 29 EP - 32 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 14 IS - 1 N2 - Structural optimization of pyrazolopyridine derivative 2, which is one of the newly discovered chemical leads for PDE4 inhibitors from our in-house library, was carried out successfully. The process of discovery of new orally active PDE4 inhibitors, which are expected to possess therapeutic potential, is presented and their structure-activity relationships are discussed. SN - 0960-894X UR - https://www.unboundmedicine.com/medline/citation/14684291/New_orally_active_PDE4_inhibitors_with_therapeutic_potential_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960894X03011120 DB - PRIME DP - Unbound Medicine ER -