Tags

Type your tag names separated by a space and hit enter

Highly potent PDE4 inhibitors with therapeutic potential.
Bioorg Med Chem Lett 2004; 14(1):207-10BM

Abstract

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

Authors+Show Affiliations

Minase Research Institute, Ono Pharmaceutical Co. Ltd, 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14684329

Citation

Ochiai, Hiroshi, et al. "Highly Potent PDE4 Inhibitors With Therapeutic Potential." Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 1, 2004, pp. 207-10.
Ochiai H, Ohtani T, Ishida A, et al. Highly potent PDE4 inhibitors with therapeutic potential. Bioorg Med Chem Lett. 2004;14(1):207-10.
Ochiai, H., Ohtani, T., Ishida, A., Kusumi, K., Kato, M., Kohno, H., ... Toda, M. (2004). Highly potent PDE4 inhibitors with therapeutic potential. Bioorganic & Medicinal Chemistry Letters, 14(1), pp. 207-10.
Ochiai H, et al. Highly Potent PDE4 Inhibitors With Therapeutic Potential. Bioorg Med Chem Lett. 2004 Jan 5;14(1):207-10. PubMed PMID: 14684329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly potent PDE4 inhibitors with therapeutic potential. AU - Ochiai,Hiroshi, AU - Ohtani,Tazumi, AU - Ishida,Akiharu, AU - Kusumi,Kensuke, AU - Kato,Masashi, AU - Kohno,Hiroshi, AU - Kishikawa,Katuya, AU - Obata,Takaaki, AU - Nakai,Hisao, AU - Toda,Masaaki, PY - 2003/12/20/pubmed PY - 2004/8/28/medline PY - 2003/12/20/entrez SP - 207 EP - 10 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 14 IS - 1 N2 - Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo 1. Water-soluble piperidine derivatives were found to possess therapeutic potential. SN - 0960-894X UR - https://www.unboundmedicine.com/medline/citation/14684329/Highly_potent_PDE4_inhibitors_with_therapeutic_potential_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960894X03010291 DB - PRIME DP - Unbound Medicine ER -