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Therapeutic effects of angiotensin II inhibition or blockade on the progression of chronic renal disease.
Int J Clin Pract. 2003 Nov; 57(9):801-22.IJ

Abstract

Experimental and clinical research has supported the use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in diabetic, hypertensive and proteinuric nephropathies. This review will evaluate the role of angiotensin II in the progression of renal damage in kidney diseases; the diagnostic value of microalbuminuria as an early clinical sign of renal damage and the possibility of preventing its further progression; the clinical results obtained with ACE inhibitors and/or ARBs in diabetic and non-diabetic nephropathies; and the therapeutic possibilities of ACE inhibitors and ARBs in renal transplantation. Based on available clinical data, ACE inhibitors can be considered to be the gold standard in reducing and/or preventing albuminuria, and thereby decreasing the percentage of patients who will progress to end-stage renal disease and death. Renal transplantation and chronic allograft nephropathy appear to be a promising field for the use of ACE inhibitors and ARBs.

Authors+Show Affiliations

Transplantation Unit, Necker Hospital, Paris, France.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14686572

Citation

Cantarovich, F, and B Rangoonwala. "Therapeutic Effects of Angiotensin II Inhibition or Blockade On the Progression of Chronic Renal Disease." International Journal of Clinical Practice, vol. 57, no. 9, 2003, pp. 801-22.
Cantarovich F, Rangoonwala B. Therapeutic effects of angiotensin II inhibition or blockade on the progression of chronic renal disease. Int J Clin Pract. 2003;57(9):801-22.
Cantarovich, F., & Rangoonwala, B. (2003). Therapeutic effects of angiotensin II inhibition or blockade on the progression of chronic renal disease. International Journal of Clinical Practice, 57(9), 801-22.
Cantarovich F, Rangoonwala B. Therapeutic Effects of Angiotensin II Inhibition or Blockade On the Progression of Chronic Renal Disease. Int J Clin Pract. 2003;57(9):801-22. PubMed PMID: 14686572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effects of angiotensin II inhibition or blockade on the progression of chronic renal disease. AU - Cantarovich,F, AU - Rangoonwala,B, PY - 2003/12/23/pubmed PY - 2004/3/23/medline PY - 2003/12/23/entrez SP - 801 EP - 22 JF - International journal of clinical practice JO - Int J Clin Pract VL - 57 IS - 9 N2 - Experimental and clinical research has supported the use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in diabetic, hypertensive and proteinuric nephropathies. This review will evaluate the role of angiotensin II in the progression of renal damage in kidney diseases; the diagnostic value of microalbuminuria as an early clinical sign of renal damage and the possibility of preventing its further progression; the clinical results obtained with ACE inhibitors and/or ARBs in diabetic and non-diabetic nephropathies; and the therapeutic possibilities of ACE inhibitors and ARBs in renal transplantation. Based on available clinical data, ACE inhibitors can be considered to be the gold standard in reducing and/or preventing albuminuria, and thereby decreasing the percentage of patients who will progress to end-stage renal disease and death. Renal transplantation and chronic allograft nephropathy appear to be a promising field for the use of ACE inhibitors and ARBs. SN - 1368-5031 UR - https://www.unboundmedicine.com/medline/citation/14686572/Therapeutic_effects_of_angiotensin_II_inhibition_or_blockade_on_the_progression_of_chronic_renal_disease_ L2 - https://medlineplus.gov/diabetickidneyproblems.html DB - PRIME DP - Unbound Medicine ER -