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Different risk factors for the maximum and the mean carotid intima-media thickness in hemodialysis patients.
Intern Med 2003; 42(11):1095-9IM

Abstract

OBJECTIVE

High-resolution B-mode ultrasonography has been widely used for the noninvasive assessment of atherosclerosis in hemodialysis patients. But, there are two major methods of carotid ultrasonography: one including plaque and the other excluding plaque.

METHODS

The subjects were 112 hemodialysis patients (58 men and 54 women) with a mean age of 55.8 +/- 13.0 years. The maximum intima-media thickness (IMT) of the carotid artery (including plaque) was measured as an index of arterial wall thickening and atheroma formation, while the mean IMT (without plaque) was measured as an index of arterial wall thickening. In addition the value of (maximum-mean) IMT was calculated as an index of atheroma formation. Therefore, the independent risk factors associated with the maximum IMT, mean IMT, and (maximum-mean) IMT were investigated by stepwise multiple regression analysis.

RESULTS

The independent risk factors associated with the maximum IMT were age, diabetes mellitus, smoking, and intact parathyroid hormone (PTH) (R = 0.569, p < 0.0001), while factors associated with the mean IMT were age, hypertension, dyslipidemia, intact PTH, and lipoprotein (a) (R = 0.602, p < 0.0001). The independent risk factors associated with the (maximum-mean) IMT were age, diabetes mellitus, smoking, and intact PTH (R = 0.515, p < 0.0001).

CONCLUSION

These findings suggest that risk factors for the maximum IMT and mean IMT are somewhat different in hemodialysis patients.

Authors+Show Affiliations

Department of Internal Medicine, Harada Hospital, Hiroshima.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14686748

Citation

Nakashima, Ayumu, et al. "Different Risk Factors for the Maximum and the Mean Carotid Intima-media Thickness in Hemodialysis Patients." Internal Medicine (Tokyo, Japan), vol. 42, no. 11, 2003, pp. 1095-9.
Nakashima A, Yorioka N, Asakimori Y, et al. Different risk factors for the maximum and the mean carotid intima-media thickness in hemodialysis patients. Intern Med. 2003;42(11):1095-9.
Nakashima, A., Yorioka, N., Asakimori, Y., Ito, T., Masaki, T., Shigemoto, K., & Harada, S. (2003). Different risk factors for the maximum and the mean carotid intima-media thickness in hemodialysis patients. Internal Medicine (Tokyo, Japan), 42(11), pp. 1095-9.
Nakashima A, et al. Different Risk Factors for the Maximum and the Mean Carotid Intima-media Thickness in Hemodialysis Patients. Intern Med. 2003;42(11):1095-9. PubMed PMID: 14686748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different risk factors for the maximum and the mean carotid intima-media thickness in hemodialysis patients. AU - Nakashima,Ayumu, AU - Yorioka,Noriaki, AU - Asakimori,Yukiteru, AU - Ito,Takafumi, AU - Masaki,Takao, AU - Shigemoto,Kenichiro, AU - Harada,Satoru, PY - 2003/12/23/pubmed PY - 2004/4/2/medline PY - 2003/12/23/entrez SP - 1095 EP - 9 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 42 IS - 11 N2 - OBJECTIVE: High-resolution B-mode ultrasonography has been widely used for the noninvasive assessment of atherosclerosis in hemodialysis patients. But, there are two major methods of carotid ultrasonography: one including plaque and the other excluding plaque. METHODS: The subjects were 112 hemodialysis patients (58 men and 54 women) with a mean age of 55.8 +/- 13.0 years. The maximum intima-media thickness (IMT) of the carotid artery (including plaque) was measured as an index of arterial wall thickening and atheroma formation, while the mean IMT (without plaque) was measured as an index of arterial wall thickening. In addition the value of (maximum-mean) IMT was calculated as an index of atheroma formation. Therefore, the independent risk factors associated with the maximum IMT, mean IMT, and (maximum-mean) IMT were investigated by stepwise multiple regression analysis. RESULTS: The independent risk factors associated with the maximum IMT were age, diabetes mellitus, smoking, and intact parathyroid hormone (PTH) (R = 0.569, p < 0.0001), while factors associated with the mean IMT were age, hypertension, dyslipidemia, intact PTH, and lipoprotein (a) (R = 0.602, p < 0.0001). The independent risk factors associated with the (maximum-mean) IMT were age, diabetes mellitus, smoking, and intact PTH (R = 0.515, p < 0.0001). CONCLUSION: These findings suggest that risk factors for the maximum IMT and mean IMT are somewhat different in hemodialysis patients. SN - 0918-2918 UR - https://www.unboundmedicine.com/medline/citation/14686748/Different_risk_factors_for_the_maximum_and_the_mean_carotid_intima_media_thickness_in_hemodialysis_patients_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/42.1095?from=PubMed DB - PRIME DP - Unbound Medicine ER -