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Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population.

Abstract

AIM

To measure the prevalence of gastro-oesophageal reflux symptoms and to identify associated factors in a representative sample of the Spanish population.

METHODS

A telephone survey of 2500 subjects was performed using a validated questionnaire. The association of gastro-oesophageal reflux symptoms (defined as the presence of heartburn or acid regurgitation) and their clinical characteristics with potential risk factors was summarized using the odds ratios (OR) obtained by multiple logistic regression.

RESULTS

The response rate was 71.2%. The annual prevalence of gastro-oesophageal reflux symptoms was 31.6% [95% confidence interval (CI), 29.8-33.4] and the weekly prevalence was 9.8% (95% CI, 8.6-10.9). Gastro-oesophageal reflux symptoms were associated with excess weight (OR, 1.53; 95% CI, 1.23-1.92), obesity (OR, 1.74; 95% CI, 1.30-2.32), the psychosomatic symptom score (OR, 2.98; 95% CI, 2.41-3.67) and the presence of gastro-oesophageal reflux symptoms in a direct family member (OR, 1.61; 95% CI, 1.17-2.23). Gastro-oesophageal reflux symptoms of > or =10 years' duration were more frequent in obese subjects (OR, 1.92; 95% CI, 1.14-3.22) and those with a direct family member with gastro-oesophageal reflux symptoms (OR, 2.42; 95% CI, 1.44-4.06). Factors associated with gastro-oesophageal reflux symptoms of < or =1 year duration were a spouse with gastro-oesophageal reflux symptoms (OR, 2.33; 95% CI, 1.39-3.9) and the consumption of 1-5 aspirins/week (OR, 1.70; 95% CI, 1.01-2.86).

CONCLUSIONS

The prevalence of frequent gastro-oesophageal reflux symptoms in Spain is lower than that observed in other Western populations. The psychosomatic symptom score is the factor most strongly associated with gastro-oesophageal reflux symptoms. Long-term gastro-oesophageal reflux symptoms are associated with certain genetic factors (obesity, family history of gastro-oesophageal reflux symptoms), whereas short-term gastro-oesophageal reflux symptoms are associated with factors of probable environmental nature.

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  • Authors+Show Affiliations

    ,

    Service of Digestive Diseases, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain. apadig@hcsc.insalud.es

    , , ,

    Source

    Alimentary pharmacology & therapeutics 19:1 2004 Jan 01 pg 95-105

    MeSH

    Adult
    Aged
    Female
    Gastroesophageal Reflux
    Heartburn
    Humans
    Male
    Middle Aged
    Odds Ratio
    Prevalence
    Regression Analysis
    Risk Factors
    Spain
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    14687171

    Citation

    Diaz-Rubio, M, et al. "Symptoms of Gastro-oesophageal Reflux: Prevalence, Severity, Duration and Associated Factors in a Spanish Population." Alimentary Pharmacology & Therapeutics, vol. 19, no. 1, 2004, pp. 95-105.
    Diaz-Rubio M, Moreno-Elola-Olaso C, Rey E, et al. Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. Aliment Pharmacol Ther. 2004;19(1):95-105.
    Diaz-Rubio, M., Moreno-Elola-Olaso, C., Rey, E., Locke, G. R., & Rodriguez-Artalejo, F. (2004). Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. Alimentary Pharmacology & Therapeutics, 19(1), pp. 95-105.
    Diaz-Rubio M, et al. Symptoms of Gastro-oesophageal Reflux: Prevalence, Severity, Duration and Associated Factors in a Spanish Population. Aliment Pharmacol Ther. 2004 Jan 1;19(1):95-105. PubMed PMID: 14687171.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. AU - Diaz-Rubio,M, AU - Moreno-Elola-Olaso,C, AU - Rey,E, AU - Locke,G R,3rd AU - Rodriguez-Artalejo,F, PY - 2003/12/23/pubmed PY - 2004/3/17/medline PY - 2003/12/23/entrez SP - 95 EP - 105 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 19 IS - 1 N2 - AIM: To measure the prevalence of gastro-oesophageal reflux symptoms and to identify associated factors in a representative sample of the Spanish population. METHODS: A telephone survey of 2500 subjects was performed using a validated questionnaire. The association of gastro-oesophageal reflux symptoms (defined as the presence of heartburn or acid regurgitation) and their clinical characteristics with potential risk factors was summarized using the odds ratios (OR) obtained by multiple logistic regression. RESULTS: The response rate was 71.2%. The annual prevalence of gastro-oesophageal reflux symptoms was 31.6% [95% confidence interval (CI), 29.8-33.4] and the weekly prevalence was 9.8% (95% CI, 8.6-10.9). Gastro-oesophageal reflux symptoms were associated with excess weight (OR, 1.53; 95% CI, 1.23-1.92), obesity (OR, 1.74; 95% CI, 1.30-2.32), the psychosomatic symptom score (OR, 2.98; 95% CI, 2.41-3.67) and the presence of gastro-oesophageal reflux symptoms in a direct family member (OR, 1.61; 95% CI, 1.17-2.23). Gastro-oesophageal reflux symptoms of > or =10 years' duration were more frequent in obese subjects (OR, 1.92; 95% CI, 1.14-3.22) and those with a direct family member with gastro-oesophageal reflux symptoms (OR, 2.42; 95% CI, 1.44-4.06). Factors associated with gastro-oesophageal reflux symptoms of < or =1 year duration were a spouse with gastro-oesophageal reflux symptoms (OR, 2.33; 95% CI, 1.39-3.9) and the consumption of 1-5 aspirins/week (OR, 1.70; 95% CI, 1.01-2.86). CONCLUSIONS: The prevalence of frequent gastro-oesophageal reflux symptoms in Spain is lower than that observed in other Western populations. The psychosomatic symptom score is the factor most strongly associated with gastro-oesophageal reflux symptoms. Long-term gastro-oesophageal reflux symptoms are associated with certain genetic factors (obesity, family history of gastro-oesophageal reflux symptoms), whereas short-term gastro-oesophageal reflux symptoms are associated with factors of probable environmental nature. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/14687171/Symptoms_of_gastro_oesophageal_reflux:_prevalence_severity_duration_and_associated_factors_in_a_Spanish_population_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=14687171.ui DB - PRIME DP - Unbound Medicine ER -