Tags

Type your tag names separated by a space and hit enter

Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial.

Abstract

OBJECTIVES

To test the hypothesis that a micronutrient supplement can improve seroconversion after influenza immunization in older institutionalized people.

DESIGN

: Randomized, double-blind, placebo-controlled study.

SETTING

Nursing and residential homes in Liverpool, United Kingdom.

PARTICIPANTS

One hundred sixty-four residents aged 60 and older from 31 homes were initially randomized; of these, 119 (72.6%) completed the study.

INTERVENTION

Participants were randomized to receive a micronutrient supplement providing the reference nutrient intake for all vitamins and trace elements or identical placebo. Tablets were taken over an 8-week period during September and October 2000; influenza vaccine was administered 4 weeks after their commencement.

MEASUREMENTS

The hemagglutination-inhibiting antibody response as defined by a fourfold or greater titer rise over 4 weeks and assessed separately for each of the three antigens contained in the 2000/2001 influenza vaccine (A/New Caledonia/20/99 (H1N1), A/Moscow/10/99 (H3N2), B/Beijing/184/93 (B)).

RESULTS

Despite a significant increase in serum concentrations of vitamins A, C, D3, E, folate, and selenium in the supplemented group, there was no significant difference between groups (supplemented vs placebo, respectively) in the proportion of participants seroconverting to H1N1 (41% vs 49%, P=.374), H3N2 (49% vs 58%, P=.343), or B (41% vs 40%, P=.944).

CONCLUSION

A micronutrient supplement providing the reference nutrient intake administered over 8 weeks had no beneficial effect on antibody response to influenza vaccine in older people living in long-term care.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Departments of Geriatric Medicine, Clinical Chemistry, and Mathematical Sciences, University of Liverpool, Liverpool, United Kingdom. stephenallsup@tinyworld.co.uk

    , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Antibody Formation
    Chi-Square Distribution
    Dietary Supplements
    Double-Blind Method
    England
    Female
    Folic Acid
    Humans
    Influenza Vaccines
    Influenza, Human
    Institutionalization
    Male
    Micronutrients
    Middle Aged
    Selenium
    Statistics, Nonparametric
    Vitamins

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14687310

    Citation

    Allsup, Stephen J., et al. "Can a Short Period of Micronutrient Supplementation in Older Institutionalized People Improve Response to Influenza Vaccine? a Randomized, Controlled Trial." Journal of the American Geriatrics Society, vol. 52, no. 1, 2004, pp. 20-4.
    Allsup SJ, Shenkin A, Gosney MA, et al. Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial. J Am Geriatr Soc. 2004;52(1):20-4.
    Allsup, S. J., Shenkin, A., Gosney, M. A., Taylor, S., Taylor, W., Hammond, M., & Zambon, M. C. (2004). Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial. Journal of the American Geriatrics Society, 52(1), pp. 20-4.
    Allsup SJ, et al. Can a Short Period of Micronutrient Supplementation in Older Institutionalized People Improve Response to Influenza Vaccine? a Randomized, Controlled Trial. J Am Geriatr Soc. 2004;52(1):20-4. PubMed PMID: 14687310.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial. AU - Allsup,Stephen J, AU - Shenkin,Alan, AU - Gosney,Margot A, AU - Taylor,Stephen, AU - Taylor,William, AU - Hammond,Margaret, AU - Zambon,Maria C, PY - 2003/12/23/pubmed PY - 2004/3/19/medline PY - 2003/12/23/entrez SP - 20 EP - 4 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 52 IS - 1 N2 - OBJECTIVES: To test the hypothesis that a micronutrient supplement can improve seroconversion after influenza immunization in older institutionalized people. DESIGN: : Randomized, double-blind, placebo-controlled study. SETTING: Nursing and residential homes in Liverpool, United Kingdom. PARTICIPANTS: One hundred sixty-four residents aged 60 and older from 31 homes were initially randomized; of these, 119 (72.6%) completed the study. INTERVENTION: Participants were randomized to receive a micronutrient supplement providing the reference nutrient intake for all vitamins and trace elements or identical placebo. Tablets were taken over an 8-week period during September and October 2000; influenza vaccine was administered 4 weeks after their commencement. MEASUREMENTS: The hemagglutination-inhibiting antibody response as defined by a fourfold or greater titer rise over 4 weeks and assessed separately for each of the three antigens contained in the 2000/2001 influenza vaccine (A/New Caledonia/20/99 (H1N1), A/Moscow/10/99 (H3N2), B/Beijing/184/93 (B)). RESULTS: Despite a significant increase in serum concentrations of vitamins A, C, D3, E, folate, and selenium in the supplemented group, there was no significant difference between groups (supplemented vs placebo, respectively) in the proportion of participants seroconverting to H1N1 (41% vs 49%, P=.374), H3N2 (49% vs 58%, P=.343), or B (41% vs 40%, P=.944). CONCLUSION: A micronutrient supplement providing the reference nutrient intake administered over 8 weeks had no beneficial effect on antibody response to influenza vaccine in older people living in long-term care. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/14687310/Can_a_short_period_of_micronutrient_supplementation_in_older_institutionalized_people_improve_response_to_influenza_vaccine_A_randomized_controlled_trial_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=2004&volume=52&issue=1&spage=20 DB - PRIME DP - Unbound Medicine ER -