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[Preliminary study on the association of chemokine RANTES gene polymorphisms with HIV-1 infection in Chinese Han population].
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Nov; 24(11):971-5.ZL

Abstract

OBJECTIVE

To detect the single nucleotide polymorphism (SNP) of chemokine regulated upon activation, normal T cell expressed and secreted (RANTES) promoter and first intron of asymptomatic, human immunodeficiency virus 1 (HIV-1) infected individuals of in Han Chinese and evaluate the influence on HIV-1 infection by variants.

METHODS

Case-control study was adopted, Genotypes of RANTES promoter -403 and -28 from 538 samples and RANTES first intron In1.1 from 300 samples of Han Chinese were detected by DNA sequencing or by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

There were six genotypes of RANTES promoter -403 and -28 found in Han Chinese group. The distribution of genotypes was AC/AC 12.4%, AC/AG 3.5%, AC/GC 29.2%, AG/GC 10.9%, GC/GC 42.1%, AG/AG 1.5%. The haplotypes was GC 62.7%, AC 28.7%, AG 8.6%. Compared with AC/AC, Odd ratio (OR) of RANTES genotypes AC/AG, AC/GC, AG/GC, GC/GC was associated with weaker reduced susceptibility to HIV-1 infection. However, there were no significant contents of the allele frequencies between people living with HIV-1 and healthy individuals. The distribution of RANTES In1.1 alleles were T/T 71.0%, C/T 19.9%, C/C 9.1% and haplotypes were RANTES In1.1T 81%, In1.1C 19%, respectively; There were significant differences of RANTES In1.1 between people with HIV-1 infection and healthy individuals in males. The In1.1C-bearing genotypes would increase susceptibility to HIV-1 infection but no significant differences in females were found. Strong linkage disequilibrium was observed between all of the three RANTES SNPs.

CONCLUSION

The two -403A/G, -28C/G variants in RANTES promoter region and intron In1.1 T/C mutation genotype were found to be associated with the genetic susceptibility to HIV-1 infection among the Han Chinese. However, the In1.1C allele or its haplotypes in RANTES intron 1 displayed a stronger dominant association with HIV-1 infection in males.

Authors+Show Affiliations

The Department of Epidemiology, Fourth Military Medical University, Xi'an 710032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

14687494

Citation

Liu, Xue-Lin, et al. "[Preliminary Study On the Association of Chemokine RANTES Gene Polymorphisms With HIV-1 Infection in Chinese Han Population]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 24, no. 11, 2003, pp. 971-5.
Liu XL, Wang FS, Jin L, et al. [Preliminary study on the association of chemokine RANTES gene polymorphisms with HIV-1 infection in Chinese Han population]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003;24(11):971-5.
Liu, X. L., Wang, F. S., Jin, L., Liu, M. X., & Xu, D. Z. (2003). [Preliminary study on the association of chemokine RANTES gene polymorphisms with HIV-1 infection in Chinese Han population]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 24(11), 971-5.
Liu XL, et al. [Preliminary Study On the Association of Chemokine RANTES Gene Polymorphisms With HIV-1 Infection in Chinese Han Population]. Zhonghua Liu Xing Bing Xue Za Zhi. 2003;24(11):971-5. PubMed PMID: 14687494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Preliminary study on the association of chemokine RANTES gene polymorphisms with HIV-1 infection in Chinese Han population]. AU - Liu,Xue-Lin, AU - Wang,Fu-Sheng, AU - Jin,Lei, AU - Liu,Ming-Xu, AU - Xu,De-Zhong, PY - 2003/12/23/pubmed PY - 2004/5/21/medline PY - 2003/12/23/entrez SP - 971 EP - 5 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 24 IS - 11 N2 - OBJECTIVE: To detect the single nucleotide polymorphism (SNP) of chemokine regulated upon activation, normal T cell expressed and secreted (RANTES) promoter and first intron of asymptomatic, human immunodeficiency virus 1 (HIV-1) infected individuals of in Han Chinese and evaluate the influence on HIV-1 infection by variants. METHODS: Case-control study was adopted, Genotypes of RANTES promoter -403 and -28 from 538 samples and RANTES first intron In1.1 from 300 samples of Han Chinese were detected by DNA sequencing or by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: There were six genotypes of RANTES promoter -403 and -28 found in Han Chinese group. The distribution of genotypes was AC/AC 12.4%, AC/AG 3.5%, AC/GC 29.2%, AG/GC 10.9%, GC/GC 42.1%, AG/AG 1.5%. The haplotypes was GC 62.7%, AC 28.7%, AG 8.6%. Compared with AC/AC, Odd ratio (OR) of RANTES genotypes AC/AG, AC/GC, AG/GC, GC/GC was associated with weaker reduced susceptibility to HIV-1 infection. However, there were no significant contents of the allele frequencies between people living with HIV-1 and healthy individuals. The distribution of RANTES In1.1 alleles were T/T 71.0%, C/T 19.9%, C/C 9.1% and haplotypes were RANTES In1.1T 81%, In1.1C 19%, respectively; There were significant differences of RANTES In1.1 between people with HIV-1 infection and healthy individuals in males. The In1.1C-bearing genotypes would increase susceptibility to HIV-1 infection but no significant differences in females were found. Strong linkage disequilibrium was observed between all of the three RANTES SNPs. CONCLUSION: The two -403A/G, -28C/G variants in RANTES promoter region and intron In1.1 T/C mutation genotype were found to be associated with the genetic susceptibility to HIV-1 infection among the Han Chinese. However, the In1.1C allele or its haplotypes in RANTES intron 1 displayed a stronger dominant association with HIV-1 infection in males. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/14687494/[Preliminary_study_on_the_association_of_chemokine_RANTES_gene_polymorphisms_with_HIV_1_infection_in_Chinese_Han_population]_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -