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The TIMPs tango with MMPs and more in the central nervous system.
J Neurosci Res. 2004 Jan 01; 75(1):1-11.JN

Abstract

The matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular proteases that have been implicated in CNS development and disease. Crucial homeostatic regulation of MMPs is mediated through the expression and actions of the tissue inhibitors of metalloproteinases (TIMPs). Although the TIMPs are recognized inhibitors of the MMPs, recent studies have revealed that these proteins also can exhibit biological activities that are distinct from their interactions with or inhibition of the MMPs. With our understanding of the roles of the TIMPs in the CNS continuously emerging, this review examines the current state of knowledge regarding the multifarious and novel functions of this family of proteins, with particular attention to their increasing potential in the development, plasticity, and pathology of the CNS.

Authors+Show Affiliations

Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

14689443

Citation

Crocker, Stephen J., et al. "The TIMPs Tango With MMPs and More in the Central Nervous System." Journal of Neuroscience Research, vol. 75, no. 1, 2004, pp. 1-11.
Crocker SJ, Pagenstecher A, Campbell IL. The TIMPs tango with MMPs and more in the central nervous system. J Neurosci Res. 2004;75(1):1-11.
Crocker, S. J., Pagenstecher, A., & Campbell, I. L. (2004). The TIMPs tango with MMPs and more in the central nervous system. Journal of Neuroscience Research, 75(1), 1-11.
Crocker SJ, Pagenstecher A, Campbell IL. The TIMPs Tango With MMPs and More in the Central Nervous System. J Neurosci Res. 2004 Jan 1;75(1):1-11. PubMed PMID: 14689443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The TIMPs tango with MMPs and more in the central nervous system. AU - Crocker,Stephen J, AU - Pagenstecher,Axel, AU - Campbell,Iain L, PY - 2003/12/23/pubmed PY - 2004/2/24/medline PY - 2003/12/23/entrez SP - 1 EP - 11 JF - Journal of neuroscience research JO - J Neurosci Res VL - 75 IS - 1 N2 - The matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular proteases that have been implicated in CNS development and disease. Crucial homeostatic regulation of MMPs is mediated through the expression and actions of the tissue inhibitors of metalloproteinases (TIMPs). Although the TIMPs are recognized inhibitors of the MMPs, recent studies have revealed that these proteins also can exhibit biological activities that are distinct from their interactions with or inhibition of the MMPs. With our understanding of the roles of the TIMPs in the CNS continuously emerging, this review examines the current state of knowledge regarding the multifarious and novel functions of this family of proteins, with particular attention to their increasing potential in the development, plasticity, and pathology of the CNS. SN - 0360-4012 UR - https://www.unboundmedicine.com/medline/citation/14689443/The_TIMPs_tango_with_MMPs_and_more_in_the_central_nervous_system_ L2 - https://doi.org/10.1002/jnr.10836 DB - PRIME DP - Unbound Medicine ER -