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Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas.
Nutr Cancer 2003; 46(2):125-30NC

Abstract

Selenoproteins such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR), and selenoprotein P (SePP) contain molecular selenium in form of selenocysteines within their active center. They are involved in the defense of reactive oxygen species, which otherwise may cause DNA damage and alterations of protein function. Selenium intake has been linked to colon carcinogenesis in epidemiological and interventional studies. In a double-blinded, placebo-controlled trial, we demonstrate that carriers of colon adenomas present with low basal serum levels of selenium and plasma glutathione peroxidase (pGPx) activity before treatment, but both parameters can be normalized by interventional selenium supplementation. GPx activity in colon mucosa was enhanced in the verum group, albeit this had only borderline significance. No change of activity was observed for mucosal TrxR activity on selenium supplementation. In summary, our results confirm the existence of low selenium levels in patients prone to colon adenomas and show that by selenium supplementation this can be normalized. If prospective trials confirm that selenium supplementation reduces colon cancer incidence rates, it may be concluded that selenium supplementation should be recommended for patients at risk.

Authors+Show Affiliations

Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universitat Wurzburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14690787

Citation

Al-Taie, Oliver H., et al. "Selenium Supplementation Enhances Low Selenium Levels and Stimulates Glutathione Peroxidase Activity in Peripheral Blood and Distal Colon Mucosa in Past and Present Carriers of Colon Adenomas." Nutrition and Cancer, vol. 46, no. 2, 2003, pp. 125-30.
Al-Taie OH, Seufert J, Karvar S, et al. Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas. Nutr Cancer. 2003;46(2):125-30.
Al-Taie, O. H., Seufert, J., Karvar, S., Adolph, C., Mörk, H., Scheurlen, M., ... Jakob, F. (2003). Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas. Nutrition and Cancer, 46(2), pp. 125-30.
Al-Taie OH, et al. Selenium Supplementation Enhances Low Selenium Levels and Stimulates Glutathione Peroxidase Activity in Peripheral Blood and Distal Colon Mucosa in Past and Present Carriers of Colon Adenomas. Nutr Cancer. 2003;46(2):125-30. PubMed PMID: 14690787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas. AU - Al-Taie,Oliver H, AU - Seufert,Jochen, AU - Karvar,Serhan, AU - Adolph,Christian, AU - Mörk,Hubert, AU - Scheurlen,Michael, AU - Köhrle,Josef, AU - Jakob,Franz, PY - 2003/12/24/pubmed PY - 2004/5/27/medline PY - 2003/12/24/entrez SP - 125 EP - 30 JF - Nutrition and cancer JO - Nutr Cancer VL - 46 IS - 2 N2 - Selenoproteins such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR), and selenoprotein P (SePP) contain molecular selenium in form of selenocysteines within their active center. They are involved in the defense of reactive oxygen species, which otherwise may cause DNA damage and alterations of protein function. Selenium intake has been linked to colon carcinogenesis in epidemiological and interventional studies. In a double-blinded, placebo-controlled trial, we demonstrate that carriers of colon adenomas present with low basal serum levels of selenium and plasma glutathione peroxidase (pGPx) activity before treatment, but both parameters can be normalized by interventional selenium supplementation. GPx activity in colon mucosa was enhanced in the verum group, albeit this had only borderline significance. No change of activity was observed for mucosal TrxR activity on selenium supplementation. In summary, our results confirm the existence of low selenium levels in patients prone to colon adenomas and show that by selenium supplementation this can be normalized. If prospective trials confirm that selenium supplementation reduces colon cancer incidence rates, it may be concluded that selenium supplementation should be recommended for patients at risk. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/14690787/Selenium_supplementation_enhances_low_selenium_levels_and_stimulates_glutathione_peroxidase_activity_in_peripheral_blood_and_distal_colon_mucosa_in_past_and_present_carriers_of_colon_adenomas_ L2 - http://www.tandfonline.com/doi/full/10.1207/S15327914NC4602_04 DB - PRIME DP - Unbound Medicine ER -