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Cancer in first-degree relatives and risk of glioma in adults.

Abstract

Relatively few studies have examined glioma risk in relation to history of cancer in first-degree relatives. We sought to describe such risks in a large hospital-based case-control study. Histologically confirmed incident adult glioma cases (n = 489) were identified at three regional referral hospitals between June 1994 and August 1998. Controls (n = 799) admitted to the same hospitals for nonmalignant conditions were frequency-matched on age, sex, race/ethnicity, hospital, and proximity of residence to hospital. Participants received a personal interview, including questions regarding cancer in family members. Odds ratios (ORs) were calculated to estimate the risk of glioma associated with a history of cancer in a first-degree relative using conditional logistic regression and compared with standardized incidence ratios among relatives of cases versus relatives of controls. Among participants reporting a family history of a brain cancer or a brain tumor, risk of glioma was 1.6 [95% confidence interval (CI), 0.5-5.3; n = 5] and 3.0 (95% CI, 0.9-10.8; n = 7), respectively, in comparison with those without such family histories. Participants who had a family history of stomach (OR, 2.2; 95% CI, 1.0-4.6), colon (OR, 1.4; 95% CI, 0.9-2.2), or prostate cancer (OR, 2.1; 95% CI, 1.1-3.8) or Hodgkin disease (OR, 2.4; 95% CI, 0.9-6.3) had an increased glioma risk. OR estimates were similar to the ratios of standardized incidence ratios for cancer in relatives of cases versus controls. Shared environmental or genetic factors in families may influence glioma risk. Our findings suggest that individuals with a family history of specific cancers other than glioma may have an increased glioma risk.

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  • Authors+Show Affiliations

    ,

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7238, USA.

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    Source

    MeSH

    Adolescent
    Adult
    Age Distribution
    Aged
    Brain Neoplasms
    Case-Control Studies
    Confidence Intervals
    Female
    Genetic Predisposition to Disease
    Glioma
    Heterozygote
    Humans
    Incidence
    Logistic Models
    Male
    Middle Aged
    Odds Ratio
    Pedigree
    Probability
    Reference Values
    Retrospective Studies
    Risk Assessment
    Sex Distribution
    Survival Analysis

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    14693735

    Citation

    Hill, Deirdre A., et al. "Cancer in First-degree Relatives and Risk of Glioma in Adults." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 12, 2003, pp. 1443-8.
    Hill DA, Inskip PD, Shapiro WR, et al. Cancer in first-degree relatives and risk of glioma in adults. Cancer Epidemiol Biomarkers Prev. 2003;12(12):1443-8.
    Hill, D. A., Inskip, P. D., Shapiro, W. R., Selker, R. G., Fine, H. A., Black, P. M., & Linet, M. S. (2003). Cancer in first-degree relatives and risk of glioma in adults. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(12), pp. 1443-8.
    Hill DA, et al. Cancer in First-degree Relatives and Risk of Glioma in Adults. Cancer Epidemiol Biomarkers Prev. 2003;12(12):1443-8. PubMed PMID: 14693735.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cancer in first-degree relatives and risk of glioma in adults. AU - Hill,Deirdre A, AU - Inskip,Peter D, AU - Shapiro,William R, AU - Selker,Robert G, AU - Fine,Howard A, AU - Black,Peter M, AU - Linet,Martha S, PY - 2003/12/25/pubmed PY - 2004/4/24/medline PY - 2003/12/25/entrez SP - 1443 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 12 N2 - Relatively few studies have examined glioma risk in relation to history of cancer in first-degree relatives. We sought to describe such risks in a large hospital-based case-control study. Histologically confirmed incident adult glioma cases (n = 489) were identified at three regional referral hospitals between June 1994 and August 1998. Controls (n = 799) admitted to the same hospitals for nonmalignant conditions were frequency-matched on age, sex, race/ethnicity, hospital, and proximity of residence to hospital. Participants received a personal interview, including questions regarding cancer in family members. Odds ratios (ORs) were calculated to estimate the risk of glioma associated with a history of cancer in a first-degree relative using conditional logistic regression and compared with standardized incidence ratios among relatives of cases versus relatives of controls. Among participants reporting a family history of a brain cancer or a brain tumor, risk of glioma was 1.6 [95% confidence interval (CI), 0.5-5.3; n = 5] and 3.0 (95% CI, 0.9-10.8; n = 7), respectively, in comparison with those without such family histories. Participants who had a family history of stomach (OR, 2.2; 95% CI, 1.0-4.6), colon (OR, 1.4; 95% CI, 0.9-2.2), or prostate cancer (OR, 2.1; 95% CI, 1.1-3.8) or Hodgkin disease (OR, 2.4; 95% CI, 0.9-6.3) had an increased glioma risk. OR estimates were similar to the ratios of standardized incidence ratios for cancer in relatives of cases versus controls. Shared environmental or genetic factors in families may influence glioma risk. Our findings suggest that individuals with a family history of specific cancers other than glioma may have an increased glioma risk. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/14693735/Cancer_in_first_degree_relatives_and_risk_of_glioma_in_adults_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14693735 DB - PRIME DP - Unbound Medicine ER -