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Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study.

Abstract

Few studies have examined the association of alcohol consumption and cigarette smoking with colorectal cancer in Asian populations whose genetic susceptibility to these factors are different from Western populations. We investigated this association and the joint effect of these factors, and estimated the population-attributable fraction to clarify the public health impact on a Japanese population, based on a prospective study. We analyzed the 10-year (cohort I) and 7-year (cohort II) follow-up data of the Japan Public Health Center-based prospective study on cancer and cardiovascular disease, derived from 90,004 (42,540 male and 47,464 female) middle-aged and elderly Japanese. We identified 716 (457 in men and 259 in women) newly diagnosed cases of colorectal cancer. Both alcohol consumption and smoking were clearly associated with colorectal cancer in men, after adjusting for age, family history of colorectal cancer, body mass index, and physical exercise. Regular heavy drinking of 150 g/week or more of ethanol showed a statistically significant increased risk compared with nondrinkers: relative risks (RRs) were 1.4 [95% confidence interval (CI), 1.1-1.9] for 150-299 g/week and 2.1 (95% CI, 1.6-2.7) for 300 g/week or more. On the contrary, regular ethanol consumption was not associated with colorectal cancer (RR, 0.7; 95% CI, 0.4-1.1) in women. In terms of smoking, the RRs were 1.4 (95% CI, 1.1-1.8) for current smokers and 1.3 (95% CI, 0.98-1.7) for ex-smokers compared with never-smokers in men. The risk of smoking in women was similar to that in men, although not statistically significant. The colorectal cancer risk with 300 g/week or more of ethanol in current smokers was estimated at 3.0 (95% CI, 1.8-5.1) compared with nondrinkers among nonsmokers in men. Colorectal cancer attributable to alcohol consumption or smoking was estimated to be 46%. In conclusion, approximately half of the colorectal cancer cases may be preventable by tobacco and alcohol controls in middle-aged and elderly Japanese men.

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  • Authors+Show Affiliations

    ,

    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan.

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    Source

    MeSH

    Age Distribution
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Cohort Studies
    Colorectal Neoplasms
    Confidence Intervals
    Female
    Humans
    Japan
    Male
    Middle Aged
    Odds Ratio
    Population Surveillance
    Proportional Hazards Models
    Prospective Studies
    Public Health
    Risk Assessment
    Risk Factors
    Sex Distribution
    Smoking
    Survival Analysis

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14693743

    Citation

    Otani, Tetsuya, et al. "Alcohol Consumption, Smoking, and Subsequent Risk of Colorectal Cancer in Middle-aged and Elderly Japanese Men and Women: Japan Public Health Center-based Prospective Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 12, no. 12, 2003, pp. 1492-500.
    Otani T, Iwasaki M, Yamamoto S, et al. Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev. 2003;12(12):1492-500.
    Otani, T., Iwasaki, M., Yamamoto, S., Sobue, T., Hanaoka, T., Inoue, M., & Tsugane, S. (2003). Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 12(12), pp. 1492-500.
    Otani T, et al. Alcohol Consumption, Smoking, and Subsequent Risk of Colorectal Cancer in Middle-aged and Elderly Japanese Men and Women: Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev. 2003;12(12):1492-500. PubMed PMID: 14693743.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study. AU - Otani,Tetsuya, AU - Iwasaki,Motoki, AU - Yamamoto,Seiichiro, AU - Sobue,Tomotaka, AU - Hanaoka,Tomoyuki, AU - Inoue,Manami, AU - Tsugane,Shoichiro, AU - ,, PY - 2003/12/25/pubmed PY - 2004/4/24/medline PY - 2003/12/25/entrez SP - 1492 EP - 500 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 12 IS - 12 N2 - Few studies have examined the association of alcohol consumption and cigarette smoking with colorectal cancer in Asian populations whose genetic susceptibility to these factors are different from Western populations. We investigated this association and the joint effect of these factors, and estimated the population-attributable fraction to clarify the public health impact on a Japanese population, based on a prospective study. We analyzed the 10-year (cohort I) and 7-year (cohort II) follow-up data of the Japan Public Health Center-based prospective study on cancer and cardiovascular disease, derived from 90,004 (42,540 male and 47,464 female) middle-aged and elderly Japanese. We identified 716 (457 in men and 259 in women) newly diagnosed cases of colorectal cancer. Both alcohol consumption and smoking were clearly associated with colorectal cancer in men, after adjusting for age, family history of colorectal cancer, body mass index, and physical exercise. Regular heavy drinking of 150 g/week or more of ethanol showed a statistically significant increased risk compared with nondrinkers: relative risks (RRs) were 1.4 [95% confidence interval (CI), 1.1-1.9] for 150-299 g/week and 2.1 (95% CI, 1.6-2.7) for 300 g/week or more. On the contrary, regular ethanol consumption was not associated with colorectal cancer (RR, 0.7; 95% CI, 0.4-1.1) in women. In terms of smoking, the RRs were 1.4 (95% CI, 1.1-1.8) for current smokers and 1.3 (95% CI, 0.98-1.7) for ex-smokers compared with never-smokers in men. The risk of smoking in women was similar to that in men, although not statistically significant. The colorectal cancer risk with 300 g/week or more of ethanol in current smokers was estimated at 3.0 (95% CI, 1.8-5.1) compared with nondrinkers among nonsmokers in men. Colorectal cancer attributable to alcohol consumption or smoking was estimated to be 46%. In conclusion, approximately half of the colorectal cancer cases may be preventable by tobacco and alcohol controls in middle-aged and elderly Japanese men. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/14693743/Alcohol_consumption_smoking_and_subsequent_risk_of_colorectal_cancer_in_middle_aged_and_elderly_Japanese_men_and_women:_Japan_Public_Health_Center_based_prospective_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=14693743 DB - PRIME DP - Unbound Medicine ER -