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[The relationship between silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes].

Abstract

OBJECTIVE

To investigate the relation between the susceptibility to silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes in Chinese Hans.

METHODS

HLA-DRB1 * and DQB1 * gene polymorphism were tested in 48 silicosis patients and 100 normal controls by using polymerase chain reaction of sequence-specific primers (PCR-SSP).

RESULTS

The allele frequencies of DRB1 * 1401 and DQB1 * 05 in silicosis patients were significantly higher than those in normal controls (chi 2 = 5.61, P = 0.0066, RR = 17.40; chi 2 = 10.70, P = 0.0011, RR = 3.81, respectively), while the allele frequency of DRB1 * 09 was significantly lower in silicosis patients than that in controls (chi 2 = 5.70, P = 0.0187, RR = 0.21). There was a significant difference between the patient group and control group.

CONCLUSION

HLA-DRB1 * 1401 and DQB1 * 05 may be the susceptible genes and HLA-DRB1 * 09 the protection gene of silicosis, both susceptibility and protection may be related to HLA-DR gene locus. The joint action of allele genes may affect the pathogenesis of silicosis.

Authors+Show Affiliations

Department of Clinical Laboratory, Attached Kai Luan Hospital of North China Coal Medical College, Tangshan 063000, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

14694619

Citation

Yuan, Baojun, et al. "[The Relationship Between Silicosis and the Polymorphism of HLA-DRB1 *, DQB1 * Genes]." Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases, vol. 20, no. 2, 2002, pp. 93-6.
Yuan B, Zhang Z, Li H, et al. [The relationship between silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002;20(2):93-6.
Yuan, B., Zhang, Z., Li, H., Chang, Y., Liu, Z., Zou, J., Li, W., & Shan, X. (2002). [The relationship between silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases, 20(2), 93-6.
Yuan B, et al. [The Relationship Between Silicosis and the Polymorphism of HLA-DRB1 *, DQB1 * Genes]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2002;20(2):93-6. PubMed PMID: 14694619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The relationship between silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes]. AU - Yuan,Baojun, AU - Zhang,Zhixin, AU - Li,Hongfen, AU - Chang,Yanhe, AU - Liu,Zhizhong, AU - Zou,Jimin, AU - Li,Wei, AU - Shan,Xiaoyan, PY - 2003/12/26/pubmed PY - 2008/7/3/medline PY - 2003/12/26/entrez SP - 93 EP - 6 JF - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases JO - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi VL - 20 IS - 2 N2 - OBJECTIVE: To investigate the relation between the susceptibility to silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes in Chinese Hans. METHODS: HLA-DRB1 * and DQB1 * gene polymorphism were tested in 48 silicosis patients and 100 normal controls by using polymerase chain reaction of sequence-specific primers (PCR-SSP). RESULTS: The allele frequencies of DRB1 * 1401 and DQB1 * 05 in silicosis patients were significantly higher than those in normal controls (chi 2 = 5.61, P = 0.0066, RR = 17.40; chi 2 = 10.70, P = 0.0011, RR = 3.81, respectively), while the allele frequency of DRB1 * 09 was significantly lower in silicosis patients than that in controls (chi 2 = 5.70, P = 0.0187, RR = 0.21). There was a significant difference between the patient group and control group. CONCLUSION: HLA-DRB1 * 1401 and DQB1 * 05 may be the susceptible genes and HLA-DRB1 * 09 the protection gene of silicosis, both susceptibility and protection may be related to HLA-DR gene locus. The joint action of allele genes may affect the pathogenesis of silicosis. SN - 1001-9391 UR - https://www.unboundmedicine.com/medline/citation/14694619/[The_relationship_between_silicosis_and_the_polymorphism_of_HLA_DRB1___DQB1___genes]_ L2 - http://www.diseaseinfosearch.org/result/6604 DB - PRIME DP - Unbound Medicine ER -