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Xanthanolides, germacranolides, and other constituents from Carpesium longifolium.
J Nat Prod. 2003 Dec; 66(12):1554-7.JN

Abstract

Three new xanthanolides, 1-3, along with nine known compounds, were isolated from the aerial parts of Carpesium longifolium. The structures of the new compounds were elucidated as 1beta,4beta-epoxy-5beta-hydroxy-10alphaH-xantha-11(13)-en-12,8beta-olide (1), 1beta,4beta,4alpha,5beta-diepoxy-10alphaH,11alphaH-xantha-12,8beta-olide (2), and 4-acetoxy-1beta,5beta-epoxy-10alphaH-xantha-11(13)-en-12,8beta-olide (3) by spectroscopic methods including IR, EIMS, HRESIMS, and 1D and 2D NMR experiments. Parthenolide and michelenolide exhibited significant cytotoxic activity against cultured SMMC-7721 (human hepatoma) and HO-8910 (human ovarian carcinoma) cells.

Authors+Show Affiliations

Yang C
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Yuan C
No affiliation info available
Jia Z
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicAsteraceaeCell Line, TumorDrug Screening Assays, AntitumorDrugs, Chinese HerbalHumansMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalSesquiterpenesSesquiterpenes, GermacraneStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14695795

Citation

Yang, Chao, et al. "Xanthanolides, Germacranolides, and Other Constituents From Carpesium Longifolium." Journal of Natural Products, vol. 66, no. 12, 2003, pp. 1554-7.
Yang C, Yuan C, Jia Z. Xanthanolides, germacranolides, and other constituents from Carpesium longifolium. J Nat Prod. 2003;66(12):1554-7.
Yang, C., Yuan, C., & Jia, Z. (2003). Xanthanolides, germacranolides, and other constituents from Carpesium longifolium. Journal of Natural Products, 66(12), 1554-7.
Yang C, Yuan C, Jia Z. Xanthanolides, Germacranolides, and Other Constituents From Carpesium Longifolium. J Nat Prod. 2003;66(12):1554-7. PubMed PMID: 14695795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthanolides, germacranolides, and other constituents from Carpesium longifolium. AU - Yang,Chao, AU - Yuan,Chengshan, AU - Jia,Zhongjian, PY - 2003/12/30/pubmed PY - 2004/3/26/medline PY - 2003/12/30/entrez SP - 1554 EP - 7 JF - Journal of natural products JO - J Nat Prod VL - 66 IS - 12 N2 - Three new xanthanolides, 1-3, along with nine known compounds, were isolated from the aerial parts of Carpesium longifolium. The structures of the new compounds were elucidated as 1beta,4beta-epoxy-5beta-hydroxy-10alphaH-xantha-11(13)-en-12,8beta-olide (1), 1beta,4beta,4alpha,5beta-diepoxy-10alphaH,11alphaH-xantha-12,8beta-olide (2), and 4-acetoxy-1beta,5beta-epoxy-10alphaH-xantha-11(13)-en-12,8beta-olide (3) by spectroscopic methods including IR, EIMS, HRESIMS, and 1D and 2D NMR experiments. Parthenolide and michelenolide exhibited significant cytotoxic activity against cultured SMMC-7721 (human hepatoma) and HO-8910 (human ovarian carcinoma) cells. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/14695795/Xanthanolides_germacranolides_and_other_constituents_from_Carpesium_longifolium_ DB - PRIME DP - Unbound Medicine ER -