Tags

Type your tag names separated by a space and hit enter

Prognosis of patients with a diagnosis of fatty liver--a registry-based cohort study.
Hepatogastroenterology. 2003 Nov-Dec; 50(54):2101-4.H

Abstract

BACKGROUND/AIMS

There are very limited data available regarding the prognosis of patients with fatty liver. We examined the overall and cause-specific mortality of fatty liver patients in a large Danish cohort.

METHODOLOGY

In the Danish National Registry of Patients, we identified 7,372 patients discharged with a diagnosis of fatty liver from a Danish hospital between 1977 and 1993. Causes of death were identified in the Danish Death Registry. We estimated the standardized mortality ratio by comparing with the general population.

RESULTS

Most patients (76%) had alcoholic fatty liver. During follow-up, 2,914 (40%) died. The commonest cause of death was hepatobiliary disease (25% of deaths). Mortality was increased 5.4-fold (95% CI 5.2-5.6) in patients with alcoholic fatty liver, and 2.6-fold (95% CI 2.4-2.9) in patients with non-alcoholic or unspecified fatty liver. Overall, in the first year of follow-up, mortality was increased more than 7-fold, almost 5-fold in the second to fifth years, and more than 3-fold after that. Mortality was similar among genders and among diabetics and non-diabetics, and remained increased after censoring patients upon diagnosis of liver cirrhosis.

CONCLUSIONS

The mortality of patients with a hospital discharge diagnosis of fatty liver was higher than that of the general population.

Authors+Show Affiliations

Jepsen P
Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg Hospital, Denmark. pj@soci.au.dk
Vilstrup H
No affiliation info available
Mellemkjaer L
No affiliation info available
Thulstrup AM
No affiliation info available
Olsen JH
No affiliation info available
Baron JA
No affiliation info available
Sørensen HT
No affiliation info available

MeSH

Cause of DeathCohort StudiesDenmarkFatty LiverFatty Liver, AlcoholicFemaleFollow-Up StudiesHumansMaleRegistriesSurvival Analysis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14696473

Citation

Jepsen, Peter, et al. "Prognosis of Patients With a Diagnosis of Fatty Liver--a Registry-based Cohort Study." Hepato-gastroenterology, vol. 50, no. 54, 2003, pp. 2101-4.
Jepsen P, Vilstrup H, Mellemkjaer L, et al. Prognosis of patients with a diagnosis of fatty liver--a registry-based cohort study. Hepatogastroenterology. 2003;50(54):2101-4.
Jepsen, P., Vilstrup, H., Mellemkjaer, L., Thulstrup, A. M., Olsen, J. H., Baron, J. A., & Sørensen, H. T. (2003). Prognosis of patients with a diagnosis of fatty liver--a registry-based cohort study. Hepato-gastroenterology, 50(54), 2101-4.
Jepsen P, et al. Prognosis of Patients With a Diagnosis of Fatty Liver--a Registry-based Cohort Study. Hepatogastroenterology. 2003 Nov-Dec;50(54):2101-4. PubMed PMID: 14696473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognosis of patients with a diagnosis of fatty liver--a registry-based cohort study. AU - Jepsen,Peter, AU - Vilstrup,Hendrik, AU - Mellemkjaer,Lene, AU - Thulstrup,Ane Marie, AU - Olsen,Jørgen H, AU - Baron,John A, AU - Sørensen,Henrik Toft, PY - 2003/12/31/pubmed PY - 2004/6/16/medline PY - 2003/12/31/entrez SP - 2101 EP - 4 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 50 IS - 54 N2 - BACKGROUND/AIMS: There are very limited data available regarding the prognosis of patients with fatty liver. We examined the overall and cause-specific mortality of fatty liver patients in a large Danish cohort. METHODOLOGY: In the Danish National Registry of Patients, we identified 7,372 patients discharged with a diagnosis of fatty liver from a Danish hospital between 1977 and 1993. Causes of death were identified in the Danish Death Registry. We estimated the standardized mortality ratio by comparing with the general population. RESULTS: Most patients (76%) had alcoholic fatty liver. During follow-up, 2,914 (40%) died. The commonest cause of death was hepatobiliary disease (25% of deaths). Mortality was increased 5.4-fold (95% CI 5.2-5.6) in patients with alcoholic fatty liver, and 2.6-fold (95% CI 2.4-2.9) in patients with non-alcoholic or unspecified fatty liver. Overall, in the first year of follow-up, mortality was increased more than 7-fold, almost 5-fold in the second to fifth years, and more than 3-fold after that. Mortality was similar among genders and among diabetics and non-diabetics, and remained increased after censoring patients upon diagnosis of liver cirrhosis. CONCLUSIONS: The mortality of patients with a hospital discharge diagnosis of fatty liver was higher than that of the general population. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/14696473/Prognosis_of_patients_with_a_diagnosis_of_fatty_liver__a_registry_based_cohort_study_ DB - PRIME DP - Unbound Medicine ER -