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Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
Am J Chin Med. 2003; 31(5):699-711.AJ

Abstract

An ethanolic extract of Parsley, Petroselinum crispum (Mill.) Nym.ex A.W. Hill (Umbelliferae), was tested for its ability to inhibit gastric secretion and to protect gastric mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, indomethacin and cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats. The extract in doses of 1 and 2 g/kg body weight had a significant antiulcerogenic activity on the models used. Besides, ethanol-induced depleted gastric wall mucus and non-protein sulfhydryl contents were replenished by pretreatment with Parsley extract. Acute toxicity tests showed a large margin of safety for the extract. The phytochemical screening of Parsley leaves revealed the presence of tannins, flavonoids, sterols and/or triterpenes.

Authors+Show Affiliations

Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14696673

Citation

Al-Howiriny, Tawfeq, et al. "Prevention of Experimentally-induced Gastric Ulcers in Rats By an Ethanolic Extract of "Parsley" Petroselinum Crispum." The American Journal of Chinese Medicine, vol. 31, no. 5, 2003, pp. 699-711.
Al-Howiriny T, Al-Sohaibani M, El-Tahir K, et al. Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum. Am J Chin Med. 2003;31(5):699-711.
Al-Howiriny, T., Al-Sohaibani, M., El-Tahir, K., & Rafatullah, S. (2003). Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum. The American Journal of Chinese Medicine, 31(5), 699-711.
Al-Howiriny T, et al. Prevention of Experimentally-induced Gastric Ulcers in Rats By an Ethanolic Extract of "Parsley" Petroselinum Crispum. Am J Chin Med. 2003;31(5):699-711. PubMed PMID: 14696673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum. AU - Al-Howiriny,Tawfeq, AU - Al-Sohaibani,Mohammed, AU - El-Tahir,Kamal, AU - Rafatullah,Syed, PY - 2003/12/31/pubmed PY - 2004/5/15/medline PY - 2003/12/31/entrez SP - 699 EP - 711 JF - The American journal of Chinese medicine JO - Am J Chin Med VL - 31 IS - 5 N2 - An ethanolic extract of Parsley, Petroselinum crispum (Mill.) Nym.ex A.W. Hill (Umbelliferae), was tested for its ability to inhibit gastric secretion and to protect gastric mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, indomethacin and cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats. The extract in doses of 1 and 2 g/kg body weight had a significant antiulcerogenic activity on the models used. Besides, ethanol-induced depleted gastric wall mucus and non-protein sulfhydryl contents were replenished by pretreatment with Parsley extract. Acute toxicity tests showed a large margin of safety for the extract. The phytochemical screening of Parsley leaves revealed the presence of tannins, flavonoids, sterols and/or triterpenes. SN - 0192-415X UR - https://www.unboundmedicine.com/medline/citation/14696673/Prevention_of_experimentally_induced_gastric_ulcers_in_rats_by_an_ethanolic_extract_of_"Parsley"_Petroselinum_crispum_ L2 - https://www.worldscientific.com/doi/10.1142/S0192415X03001405?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -