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[Hepatitis E virus: current status].
Med Clin (Barc). 2003 Dec 06; 121(20):787-92.MC

Abstract

In areas with tropical or subtropical climate and poor sanitary conditions, hepatitis E is the major cause of enterically transmitted non-A, non-B hepatitis, and is responsible for both water-borne outbreaks and sporadic cases of acute hepatitis. The causative agent is the hepatitis E virus (HEV), a non-enveloped, single-stranded, positive-sense RNA molecule of an approximately 7.2 kb length. Recently, HEV strains have been isolated in swine in industrialized countries. In addition, cases of acute hepatitis due to novel HEV variants have been reported in humans without recognized risk factors for hepatitis E in Europe, Japan and the US. Some of the novel strains were found to be closely related to swine HEV isolates from the same area, suggesting that hepatitis E is a zoonotic disease. Thus hepatitis E is becoming a concern in countries where HEV is not, traditionally, believed to be endemic. This review summarizes the current knowledge of the biology, structure and transmission of the virus as well as the diagnosis of the infection. We also analyze the present status in areas with a low incidence of acute hepatitis E and the role of animals as potencial vectors of the virus.

Authors+Show Affiliations

Departamento de Atención Sanitaria, Salud Pública y Sanidad Animal. Universidad Cardenal Herrera-CEU. Moncada. Valencia. España. teresa@uch.ceu.esNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

spa

PubMed ID

14697167

Citation

Pérez-Gracia, María Teresa, and Manuel Rodríguez-Iglesias. "[Hepatitis E Virus: Current Status]." Medicina Clinica, vol. 121, no. 20, 2003, pp. 787-92.
Pérez-Gracia MT, Rodríguez-Iglesias M. [Hepatitis E virus: current status]. Med Clin (Barc). 2003;121(20):787-92.
Pérez-Gracia, M. T., & Rodríguez-Iglesias, M. (2003). [Hepatitis E virus: current status]. Medicina Clinica, 121(20), 787-92.
Pérez-Gracia MT, Rodríguez-Iglesias M. [Hepatitis E Virus: Current Status]. Med Clin (Barc). 2003 Dec 6;121(20):787-92. PubMed PMID: 14697167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hepatitis E virus: current status]. AU - Pérez-Gracia,María Teresa, AU - Rodríguez-Iglesias,Manuel, PY - 2003/12/31/pubmed PY - 2004/3/3/medline PY - 2003/12/31/entrez SP - 787 EP - 92 JF - Medicina clinica JO - Med Clin (Barc) VL - 121 IS - 20 N2 - In areas with tropical or subtropical climate and poor sanitary conditions, hepatitis E is the major cause of enterically transmitted non-A, non-B hepatitis, and is responsible for both water-borne outbreaks and sporadic cases of acute hepatitis. The causative agent is the hepatitis E virus (HEV), a non-enveloped, single-stranded, positive-sense RNA molecule of an approximately 7.2 kb length. Recently, HEV strains have been isolated in swine in industrialized countries. In addition, cases of acute hepatitis due to novel HEV variants have been reported in humans without recognized risk factors for hepatitis E in Europe, Japan and the US. Some of the novel strains were found to be closely related to swine HEV isolates from the same area, suggesting that hepatitis E is a zoonotic disease. Thus hepatitis E is becoming a concern in countries where HEV is not, traditionally, believed to be endemic. This review summarizes the current knowledge of the biology, structure and transmission of the virus as well as the diagnosis of the infection. We also analyze the present status in areas with a low incidence of acute hepatitis E and the role of animals as potencial vectors of the virus. SN - 0025-7753 UR - https://www.unboundmedicine.com/medline/citation/14697167/[Hepatitis_E_virus:_current_status]_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0025-7753/121/787 DB - PRIME DP - Unbound Medicine ER -