Tags

Type your tag names separated by a space and hit enter

A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease.
Neurosci Lett 2004; 354(2):103-6NL

Abstract

The impact of the insertion (I)/deletion (D) (I/D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene on the extent of white matter myelin loss (ML) was investigated in four regions of the cerebral cortex in an autopsy-confirmed series of 93 patients with Alzheimer's disease (AD). The possible influence of APO E epsilon4 allele acting in concert with ACE D allele was assessed. The extent of ML did not differ between D/D, I/D and I/I genotype groups when data from all four brain regions were combined. However, separate analysis showed that the frontal and temporal cortex tended to be affected more severely by ML in patients with D/D genotype compared to those with I/D and I/I genotypes. Stratification according to APO E epsilon4 allele revealed a greater overall ML in patients bearing at least one copy of ACE D allele and one APO E epsilon4 allele, especially in individuals homozygous for both. The APO E epsilon4 allele may therefore act synergistically in patients with AD (and other subjects) bearing ACE D/D genotype to increase the risk of ML, perhaps through transient ischaemic episodes consequent upon poor cardiac output associated with coronary atherosclerosis in patients with the APO E epsilon4 allele.

Authors+Show Affiliations

Clinical Neuroscience Research Group, Department of Medicine, University of Manchester, Manchester, M13 9PT, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14698449

Citation

Tian, J, et al. "A Polymorphism in the Angiotensin 1-converting Enzyme Gene Is Associated With Damage to Cerebral Cortical White Matter in Alzheimer's Disease." Neuroscience Letters, vol. 354, no. 2, 2004, pp. 103-6.
Tian J, Shi J, Bailey K, et al. A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease. Neurosci Lett. 2004;354(2):103-6.
Tian, J., Shi, J., Bailey, K., Harris, J. M., Pritchard, A., Lambert, J. C., ... Mann, D. M. (2004). A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease. Neuroscience Letters, 354(2), pp. 103-6.
Tian J, et al. A Polymorphism in the Angiotensin 1-converting Enzyme Gene Is Associated With Damage to Cerebral Cortical White Matter in Alzheimer's Disease. Neurosci Lett. 2004 Jan 9;354(2):103-6. PubMed PMID: 14698449.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease. AU - Tian,J, AU - Shi,J, AU - Bailey,K, AU - Harris,J M, AU - Pritchard,A, AU - Lambert,J-C, AU - Chartier-Harlin,M-C, AU - Pickering-Brown,S M, AU - Lendon,C L, AU - Mann,D M A, PY - 2003/12/31/pubmed PY - 2004/3/12/medline PY - 2003/12/31/entrez SP - 103 EP - 6 JF - Neuroscience letters JO - Neurosci. Lett. VL - 354 IS - 2 N2 - The impact of the insertion (I)/deletion (D) (I/D) polymorphism in the angiotensin 1-converting enzyme (ACE) gene on the extent of white matter myelin loss (ML) was investigated in four regions of the cerebral cortex in an autopsy-confirmed series of 93 patients with Alzheimer's disease (AD). The possible influence of APO E epsilon4 allele acting in concert with ACE D allele was assessed. The extent of ML did not differ between D/D, I/D and I/I genotype groups when data from all four brain regions were combined. However, separate analysis showed that the frontal and temporal cortex tended to be affected more severely by ML in patients with D/D genotype compared to those with I/D and I/I genotypes. Stratification according to APO E epsilon4 allele revealed a greater overall ML in patients bearing at least one copy of ACE D allele and one APO E epsilon4 allele, especially in individuals homozygous for both. The APO E epsilon4 allele may therefore act synergistically in patients with AD (and other subjects) bearing ACE D/D genotype to increase the risk of ML, perhaps through transient ischaemic episodes consequent upon poor cardiac output associated with coronary atherosclerosis in patients with the APO E epsilon4 allele. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/14698449/A_polymorphism_in_the_angiotensin_1_converting_enzyme_gene_is_associated_with_damage_to_cerebral_cortical_white_matter_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394003011789 DB - PRIME DP - Unbound Medicine ER -