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The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans.
Carbohydr Res. 2004 Jan 22; 339(2):335-47.CR

Abstract

The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1'-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts of C-6 sulfate, 6-O-methyl, and nonsubstituted residues. B-units are formed mainly by 3,6-anhydro-alpha-L-galactose (15-16%) and its precursor, alpha-L-galactose 6-sulfate (10-17%), together with lesser amounts of 3,6-anhydro-alpha-L-galactose 2-sulfate, alpha-L-galactose 2,6-disulfate, alpha-L-galactose 2,3,6-tri-sulfate, alpha-L-galactose 2,6-disulfate 3-xylose, 2-O-methyl-alpha-L-galactose, and unsubstituted alpha-L-galactose. Small, but significant quantities of beta-D-xylose were found in all the fractions, together with small amounts to traces of D-glucose. Some of the fractions have high antiviral activity. Attempts to correlate structure and antiviral activity in agarans are presented.

Authors+Show Affiliations

Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, P.O. Box 19046, CEP 81531-990, Curitiba, Paraná, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14698892

Citation

Duarte, Maria E R., et al. "The Structure of the Agaran Sulfate From Acanthophora Spicifera (Rhodomelaceae, Ceramiales) and Its Antiviral Activity. Relation Between Structure and Antiviral Activity in Agarans." Carbohydrate Research, vol. 339, no. 2, 2004, pp. 335-47.
Duarte ME, Cauduro JP, Noseda DG, et al. The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans. Carbohydr Res. 2004;339(2):335-47.
Duarte, M. E., Cauduro, J. P., Noseda, D. G., Noseda, M. D., Gonçalves, A. G., Pujol, C. A., Damonte, E. B., & Cerezo, A. S. (2004). The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans. Carbohydrate Research, 339(2), 335-47.
Duarte ME, et al. The Structure of the Agaran Sulfate From Acanthophora Spicifera (Rhodomelaceae, Ceramiales) and Its Antiviral Activity. Relation Between Structure and Antiviral Activity in Agarans. Carbohydr Res. 2004 Jan 22;339(2):335-47. PubMed PMID: 14698892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The structure of the agaran sulfate from Acanthophora spicifera (Rhodomelaceae, Ceramiales) and its antiviral activity. Relation between structure and antiviral activity in agarans. AU - Duarte,Maria E R, AU - Cauduro,Jean P, AU - Noseda,Diego G, AU - Noseda,Miguel D, AU - Gonçalves,Alan G, AU - Pujol,Carlos A, AU - Damonte,Elsa B, AU - Cerezo,Alberto S, PY - 2003/12/31/pubmed PY - 2004/9/17/medline PY - 2003/12/31/entrez SP - 335 EP - 47 JF - Carbohydrate research JO - Carbohydr Res VL - 339 IS - 2 N2 - The sulfated agaran isolated by water extraction from the red seaweed, Acanthophora spicifera (Rhodomelaceae, Ceramiales), is made up of A-units highly substituted with sulfate groups on C-2 (28-30%), sulfates on C-2 and 4,6-O-(1'-carboxyethylidene) groups (9-15%), and only the C-2 sulfate groups (5-8%) with small amounts of C-6 sulfate, 6-O-methyl, and nonsubstituted residues. B-units are formed mainly by 3,6-anhydro-alpha-L-galactose (15-16%) and its precursor, alpha-L-galactose 6-sulfate (10-17%), together with lesser amounts of 3,6-anhydro-alpha-L-galactose 2-sulfate, alpha-L-galactose 2,6-disulfate, alpha-L-galactose 2,3,6-tri-sulfate, alpha-L-galactose 2,6-disulfate 3-xylose, 2-O-methyl-alpha-L-galactose, and unsubstituted alpha-L-galactose. Small, but significant quantities of beta-D-xylose were found in all the fractions, together with small amounts to traces of D-glucose. Some of the fractions have high antiviral activity. Attempts to correlate structure and antiviral activity in agarans are presented. SN - 0008-6215 UR - https://www.unboundmedicine.com/medline/citation/14698892/The_structure_of_the_agaran_sulfate_from_Acanthophora_spicifera__Rhodomelaceae_Ceramiales__and_its_antiviral_activity__Relation_between_structure_and_antiviral_activity_in_agarans_ DB - PRIME DP - Unbound Medicine ER -