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Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia.
Clin Infect Dis. 2004 Jan 15; 38(2):222-6.CI

Abstract

We evaluated the usefulness of a rapid urinary antigen test (Binax NOW; Binax) to detect Streptococcus pneumoniae for the early diagnosis of community-acquired pneumococcal pneumonia (PP) in 220 nonseverely immunosuppressed adults. We compared results of this test with those of sputum Gram staining. The rapid urinary antigen test showed limited sensitivity (65.9%; 95% confidence interval [CI], 51.4-80.4) but high specificity (100%; 95% CI, 99.7-100) for diagnosing PP. The test was more sensitive for patients with versus those without high-risk pneumonia (94% vs. 63%; P<.001) and for patients without versus those with demonstrative results of a sputum Gram stain (97% vs. 55%; P<.001), and it tended to be more sensitive for patients with versus those without bacteremic PP (92% vs. 74%; P=NS). Rapid urinary antigen testing permitted early diagnosis of PP in 26% more patients than did Gram staining but missed 22% of the rapid diagnoses initially identified by Gram staining. On the basis of our results, a sequential approach is proposed, with reservation of urinary antigen testing for high-risk patients for whom demonstrative results of a sputum Gram stain are unavailable.

Authors+Show Affiliations

Department of Infectious Diseases, Hospital Universitari de Bellvitge, University of Barcelona, Barcelona, Spain. broson@csub.scs.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14699454

Citation

Rosón, Beatriz, et al. "Contribution of a Urinary Antigen Assay (Binax NOW) to the Early Diagnosis of Pneumococcal Pneumonia." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 38, no. 2, 2004, pp. 222-6.
Rosón B, Fernández-Sabé N, Carratalà J, et al. Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia. Clin Infect Dis. 2004;38(2):222-6.
Rosón, B., Fernández-Sabé, N., Carratalà, J., Verdaguer, R., Dorca, J., Manresa, F., & Gudiol, F. (2004). Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 38(2), 222-6.
Rosón B, et al. Contribution of a Urinary Antigen Assay (Binax NOW) to the Early Diagnosis of Pneumococcal Pneumonia. Clin Infect Dis. 2004 Jan 15;38(2):222-6. PubMed PMID: 14699454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia. AU - Rosón,Beatriz, AU - Fernández-Sabé,Nuria, AU - Carratalà,Jordi, AU - Verdaguer,Ricard, AU - Dorca,Jordi, AU - Manresa,Frederic, AU - Gudiol,Francesc, Y1 - 2003/12/18/ PY - 2003/06/03/received PY - 2003/09/01/accepted PY - 2003/12/31/pubmed PY - 2004/1/28/medline PY - 2003/12/31/entrez SP - 222 EP - 6 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 38 IS - 2 N2 - We evaluated the usefulness of a rapid urinary antigen test (Binax NOW; Binax) to detect Streptococcus pneumoniae for the early diagnosis of community-acquired pneumococcal pneumonia (PP) in 220 nonseverely immunosuppressed adults. We compared results of this test with those of sputum Gram staining. The rapid urinary antigen test showed limited sensitivity (65.9%; 95% confidence interval [CI], 51.4-80.4) but high specificity (100%; 95% CI, 99.7-100) for diagnosing PP. The test was more sensitive for patients with versus those without high-risk pneumonia (94% vs. 63%; P<.001) and for patients without versus those with demonstrative results of a sputum Gram stain (97% vs. 55%; P<.001), and it tended to be more sensitive for patients with versus those without bacteremic PP (92% vs. 74%; P=NS). Rapid urinary antigen testing permitted early diagnosis of PP in 26% more patients than did Gram staining but missed 22% of the rapid diagnoses initially identified by Gram staining. On the basis of our results, a sequential approach is proposed, with reservation of urinary antigen testing for high-risk patients for whom demonstrative results of a sputum Gram stain are unavailable. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/14699454/Contribution_of_a_urinary_antigen_assay__Binax_NOW__to_the_early_diagnosis_of_pneumococcal_pneumonia_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/380639 DB - PRIME DP - Unbound Medicine ER -