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Contribution of the type 1 plasminogen activator inhibitor 4G/5G gene polymorphism to impaired fibrinolysis in vital exhaustion.
Ital Heart J. 2003 Nov; 4(11):791-6.IH

Abstract

BACKGROUND

Inappropriate coping with chronic stress may result in a state of "vital exhaustion" that has been associated with coronary artery disease. Impaired fibrinolysis due to an increase in type 1 plasminogen activator inhibitor (PAI-1) might mediate this link. Genetic and environmental factors both regulate the plasma PAI-1 levels. We investigated the contribution of the PAI-1 4G/5G gene polymorphism to the plasma levels of PAI-1 in exhaustion.

METHODS

The study participants were 258 (mean age 40.9 +/- 9.1 years) apparently healthy subjects of an airplane manufacturing plant in Germany who completed the Shortened 9-item Maastricht Vital Exhaustion Questionnaire. A median split was performed on exhaustion scores rendering two groups of exhausted and non-exhausted subjects. The PAI-1 4G/5G polymorphism in the promoter region of the PAI-1 gene and several variables related to the insulin resistance syndrome known to affect plasma PAI-1 levels were assessed.

RESULTS

Across all subjects, exhausted individuals had higher PAI-1 antigen levels than non-exhausted subjects (46.6 +/- 20.7 vs 38.3 +/- 21.4 ng/ml, p = 0.002). There were no significant differences in the PAI-1 antigen levels between exhausted and non-exhausted individuals with both the 4G/4G and the 4G/5G polymorphism. With the 5G/5G polymorphism, however, exhausted subjects had higher PAI-1 antigen levels than non-exhausted subjects (44.9 +/- 22.9 vs 31.2 +/- 13.1 ng/ml, p = 0.017). These results did not change when controlling for the variables of insulin resistance.

CONCLUSIONS

The findings suggest that the PAI-1 4G/5G gene polymorphism might affect the plasma PAI-1 levels related to exhaustion severity. With the 5G/5G polymorphism, exhausted subjects might have less fibrinolytic capacity than non-exhausted subjects.

Authors+Show Affiliations

Institute for Behavioral Sciences, Swiss Federal Institute of Technology, University Hospital, Zürich, Switzerland. roland.vonkaenel@ifv.gess.etzh.chNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14699709

Citation

von Känel, Roland, et al. "Contribution of the Type 1 Plasminogen Activator Inhibitor 4G/5G Gene Polymorphism to Impaired Fibrinolysis in Vital Exhaustion." Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, vol. 4, no. 11, 2003, pp. 791-6.
von Känel R, Maly FE, Frey K, et al. Contribution of the type 1 plasminogen activator inhibitor 4G/5G gene polymorphism to impaired fibrinolysis in vital exhaustion. Ital Heart J. 2003;4(11):791-6.
von Känel, R., Maly, F. E., Frey, K., & Fischer, J. E. (2003). Contribution of the type 1 plasminogen activator inhibitor 4G/5G gene polymorphism to impaired fibrinolysis in vital exhaustion. Italian Heart Journal : Official Journal of the Italian Federation of Cardiology, 4(11), 791-6.
von Känel R, et al. Contribution of the Type 1 Plasminogen Activator Inhibitor 4G/5G Gene Polymorphism to Impaired Fibrinolysis in Vital Exhaustion. Ital Heart J. 2003;4(11):791-6. PubMed PMID: 14699709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contribution of the type 1 plasminogen activator inhibitor 4G/5G gene polymorphism to impaired fibrinolysis in vital exhaustion. AU - von Känel,Roland, AU - Maly,Friedrich E, AU - Frey,Karl, AU - Fischer,Joachim E, PY - 2004/1/1/pubmed PY - 2004/4/24/medline PY - 2004/1/1/entrez SP - 791 EP - 6 JF - Italian heart journal : official journal of the Italian Federation of Cardiology JO - Ital Heart J VL - 4 IS - 11 N2 - BACKGROUND: Inappropriate coping with chronic stress may result in a state of "vital exhaustion" that has been associated with coronary artery disease. Impaired fibrinolysis due to an increase in type 1 plasminogen activator inhibitor (PAI-1) might mediate this link. Genetic and environmental factors both regulate the plasma PAI-1 levels. We investigated the contribution of the PAI-1 4G/5G gene polymorphism to the plasma levels of PAI-1 in exhaustion. METHODS: The study participants were 258 (mean age 40.9 +/- 9.1 years) apparently healthy subjects of an airplane manufacturing plant in Germany who completed the Shortened 9-item Maastricht Vital Exhaustion Questionnaire. A median split was performed on exhaustion scores rendering two groups of exhausted and non-exhausted subjects. The PAI-1 4G/5G polymorphism in the promoter region of the PAI-1 gene and several variables related to the insulin resistance syndrome known to affect plasma PAI-1 levels were assessed. RESULTS: Across all subjects, exhausted individuals had higher PAI-1 antigen levels than non-exhausted subjects (46.6 +/- 20.7 vs 38.3 +/- 21.4 ng/ml, p = 0.002). There were no significant differences in the PAI-1 antigen levels between exhausted and non-exhausted individuals with both the 4G/4G and the 4G/5G polymorphism. With the 5G/5G polymorphism, however, exhausted subjects had higher PAI-1 antigen levels than non-exhausted subjects (44.9 +/- 22.9 vs 31.2 +/- 13.1 ng/ml, p = 0.017). These results did not change when controlling for the variables of insulin resistance. CONCLUSIONS: The findings suggest that the PAI-1 4G/5G gene polymorphism might affect the plasma PAI-1 levels related to exhaustion severity. With the 5G/5G polymorphism, exhausted subjects might have less fibrinolytic capacity than non-exhausted subjects. SN - 1129-471X UR - https://www.unboundmedicine.com/medline/citation/14699709/Contribution_of_the_type_1_plasminogen_activator_inhibitor_4G/5G_gene_polymorphism_to_impaired_fibrinolysis_in_vital_exhaustion_ L2 - https://medlineplus.gov/fatigue.html DB - PRIME DP - Unbound Medicine ER -