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Effect of different modalities of exercise and recovery on exercise performance in subjects with sickle cell trait.

Abstract

The sickle cell trait (HbAS) does not seem to affect exercise performance. It remains unclear, however, whether the capability to sustain repeated brief maximal effort and recovery by HbAS subjects, is also preserved. To study this, nine HbAS and nine matched controls underwent on two different occasions, a series of four, approximately 2-min duration, maximal cycle exercise tests separated by 20-min recovery periods of either absolute rest (P) or light pedaling (A) as well as an incremental test to exhaustion. In all tests, work performed, heart rate, blood hematocrit, lactate, and serum creatine kinase (CK), lactate dehydrogenase (LDH), and aspartate aminotransferase (GOT) were measured. Performances were similar in HbAS and HbAA subjects in both the predominantly anaerobic and aerobic exercise series. There were no observable differences in work, power, or heart rate in the two groups both during peak exercise or recovery periods. A significant hemoconcentration was observed during P, with hematocrit increasing in HbAS from 46.4 +/- 0.7% to 48.3 +/- 0.4% at the end of the last recovery period. Similar changes were seen in HbAA. Significantly greater fluid losses were found during A (1.3 +/- 0.2 l in A and 0.6 +/- 0.1 l in P for HbAS; P < 0.001), but fluid losses were similar in each type of recovery in the two groups. Despite similar performance, significantly lower blood lactate concentrations were consistently found in HbAS in each of the three exercise series (P < 0.001). Lower lactate levels in HbAS were observed only at exercise loads above the lactate threshold during the incremental test (P < 0.05).(

ABSTRACT

TRUNCATED AT 250 WORDS)

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  • Authors+Show Affiliations

    ,

    Department of Applied Exercise Physiology, National Institute for Youth and Sports of Yaoundé (INJS), Cameroon.

    , , , , ,

    Source

    MeSH

    Adult
    Exercise
    Heart Rate
    Hematocrit
    Humans
    L-Lactate Dehydrogenase
    Lactates
    Physical Endurance
    Sickle Cell Trait

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    1470014

    Citation

    Gozal, D, et al. "Effect of Different Modalities of Exercise and Recovery On Exercise Performance in Subjects With Sickle Cell Trait." Medicine and Science in Sports and Exercise, vol. 24, no. 12, 1992, pp. 1325-31.
    Gozal D, Thiriet P, Mbala E, et al. Effect of different modalities of exercise and recovery on exercise performance in subjects with sickle cell trait. Med Sci Sports Exerc. 1992;24(12):1325-31.
    Gozal, D., Thiriet, P., Mbala, E., Wouassi, D., Gelas, H., Geyssant, A., & Lacour, J. R. (1992). Effect of different modalities of exercise and recovery on exercise performance in subjects with sickle cell trait. Medicine and Science in Sports and Exercise, 24(12), pp. 1325-31.
    Gozal D, et al. Effect of Different Modalities of Exercise and Recovery On Exercise Performance in Subjects With Sickle Cell Trait. Med Sci Sports Exerc. 1992;24(12):1325-31. PubMed PMID: 1470014.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of different modalities of exercise and recovery on exercise performance in subjects with sickle cell trait. AU - Gozal,D, AU - Thiriet,P, AU - Mbala,E, AU - Wouassi,D, AU - Gelas,H, AU - Geyssant,A, AU - Lacour,J R, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez SP - 1325 EP - 31 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 24 IS - 12 N2 - The sickle cell trait (HbAS) does not seem to affect exercise performance. It remains unclear, however, whether the capability to sustain repeated brief maximal effort and recovery by HbAS subjects, is also preserved. To study this, nine HbAS and nine matched controls underwent on two different occasions, a series of four, approximately 2-min duration, maximal cycle exercise tests separated by 20-min recovery periods of either absolute rest (P) or light pedaling (A) as well as an incremental test to exhaustion. In all tests, work performed, heart rate, blood hematocrit, lactate, and serum creatine kinase (CK), lactate dehydrogenase (LDH), and aspartate aminotransferase (GOT) were measured. Performances were similar in HbAS and HbAA subjects in both the predominantly anaerobic and aerobic exercise series. There were no observable differences in work, power, or heart rate in the two groups both during peak exercise or recovery periods. A significant hemoconcentration was observed during P, with hematocrit increasing in HbAS from 46.4 +/- 0.7% to 48.3 +/- 0.4% at the end of the last recovery period. Similar changes were seen in HbAA. Significantly greater fluid losses were found during A (1.3 +/- 0.2 l in A and 0.6 +/- 0.1 l in P for HbAS; P < 0.001), but fluid losses were similar in each type of recovery in the two groups. Despite similar performance, significantly lower blood lactate concentrations were consistently found in HbAS in each of the three exercise series (P < 0.001). Lower lactate levels in HbAS were observed only at exercise loads above the lactate threshold during the incremental test (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/1470014/Effect_of_different_modalities_of_exercise_and_recovery_on_exercise_performance_in_subjects_with_sickle_cell_trait_ L2 - http://Insights.ovid.com/pubmed?pmid=1470014 DB - PRIME DP - Unbound Medicine ER -