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[Evaluation of interleukin-13 in the serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis].
Zhonghua Jie He He Hu Xi Za Zhi. 2003 Nov; 26(11):686-8.ZJ

Abstract

OBJECTIVE

To study the significance of interleukin-13 (IL-13) in peripheral blood and bronchoalveolar lavage fluid (BALF) from patients with idiopathic pulmonary fibrosis (IPF).

METHODS

The level of IL-13 was determined with ELISA in the serum and BALF of 17 patients with IPF and 8 subjects with non-interstitial lung diseases (non-smokers).

RESULTS

The level of IL-13 in the BALF of the patients with IPF was significantly higher than that in non-interstitial lung disease group [(301 +/- 86) ng/L vs. (103 +/- 24) ng/L (P < 0.01)] and was higher than that in serum [(178 +/- 36) ng/L vs. (55 +/- 15) ng/L, P < 0.01]. The level of IL-13 in the BALF of the patients with IPF was positively correlated with the percentage of neutrophils (r = 0.786, P < 0.01). The analysis of Spearman correlation showed that the level of IL-13 in the BALF was correlated with lung function, PaO(2), and D(LCO) (Spearman correlation coefficient r = -0.898, -0.878, -0.874, -0.890, respectively, P < 0.01).

CONCLUSION

IL-13 may play an important role in the pathogenesis of IPF and be a potential marker of IPF activity.

Authors+Show Affiliations

Respiratory Disease Institute, First Affiliated Hospital, China Medical University, Shenyang 110001, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

14703444

Citation

Xiao, Li, et al. "[Evaluation of Interleukin-13 in the Serum and Bronchoalveolar Lavage Fluid of Patients With Idiopathic Pulmonary Fibrosis]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 26, no. 11, 2003, pp. 686-8.
Xiao L, Li ZH, Hou XM, et al. [Evaluation of interleukin-13 in the serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(11):686-8.
Xiao, L., Li, Z. H., Hou, X. M., & Yu, R. J. (2003). [Evaluation of interleukin-13 in the serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 26(11), 686-8.
Xiao L, et al. [Evaluation of Interleukin-13 in the Serum and Bronchoalveolar Lavage Fluid of Patients With Idiopathic Pulmonary Fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2003;26(11):686-8. PubMed PMID: 14703444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of interleukin-13 in the serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis]. AU - Xiao,Li, AU - Li,Zhen-hua, AU - Hou,Xian-ming, AU - Yu,Run-jiang, PY - 2004/1/3/pubmed PY - 2004/5/28/medline PY - 2004/1/3/entrez SP - 686 EP - 8 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 26 IS - 11 N2 - OBJECTIVE: To study the significance of interleukin-13 (IL-13) in peripheral blood and bronchoalveolar lavage fluid (BALF) from patients with idiopathic pulmonary fibrosis (IPF). METHODS: The level of IL-13 was determined with ELISA in the serum and BALF of 17 patients with IPF and 8 subjects with non-interstitial lung diseases (non-smokers). RESULTS: The level of IL-13 in the BALF of the patients with IPF was significantly higher than that in non-interstitial lung disease group [(301 +/- 86) ng/L vs. (103 +/- 24) ng/L (P < 0.01)] and was higher than that in serum [(178 +/- 36) ng/L vs. (55 +/- 15) ng/L, P < 0.01]. The level of IL-13 in the BALF of the patients with IPF was positively correlated with the percentage of neutrophils (r = 0.786, P < 0.01). The analysis of Spearman correlation showed that the level of IL-13 in the BALF was correlated with lung function, PaO(2), and D(LCO) (Spearman correlation coefficient r = -0.898, -0.878, -0.874, -0.890, respectively, P < 0.01). CONCLUSION: IL-13 may play an important role in the pathogenesis of IPF and be a potential marker of IPF activity. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/14703444/[Evaluation_of_interleukin_13_in_the_serum_and_bronchoalveolar_lavage_fluid_of_patients_with_idiopathic_pulmonary_fibrosis]_ L2 - http://www.diseaseinfosearch.org/result/6087 DB - PRIME DP - Unbound Medicine ER -