Tags

Type your tag names separated by a space and hit enter

Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops.
Pharmazie. 2003 Dec; 58(12):870-3.P

Abstract

The behaviour of dorzolamide hydrochloride (DOR) was investigated at a glassy carbon electrode in different buffer systems using cyclic (CV), linear sweep (LSV) and differential pulse voltammetry (DPV). The oxidation process was found to be irreversible over the pH range studied (2.0-8.0) and was shown to be diffusion controlled. An analytical method with adequate precision and accuracy was developed for the determination of DOR in Britton-Robinson buffer (BRb) at pH = 3.06 containing 10% methanol as supporting electrolyte. The peak current varied linearly with DOR concentration in the range 4.0 x 10(-5)-6.0 x 10(-4) M. Furthermore, a HPLC method with diode array detection was developed. A calibration graph was established for 1.1 x 10(-6)-1.9 x 10(-4) M of DOR. The procedures were successfully applied for the determination of the drug in eye drops.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandoğan-Ankara,Turkey. erk@pharmacy.ankara.edu.tr

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14703963

Citation

Erk, N. "Voltammetric and HPLC Determination of Dorzolamide Hydrochloride in Eye Drops." Die Pharmazie, vol. 58, no. 12, 2003, pp. 870-3.
Erk N. Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops. Pharmazie. 2003;58(12):870-3.
Erk, N. (2003). Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops. Die Pharmazie, 58(12), 870-3.
Erk N. Voltammetric and HPLC Determination of Dorzolamide Hydrochloride in Eye Drops. Pharmazie. 2003;58(12):870-3. PubMed PMID: 14703963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops. A1 - Erk,N, PY - 2004/1/6/pubmed PY - 2004/1/30/medline PY - 2004/1/6/entrez SP - 870 EP - 3 JF - Die Pharmazie JO - Pharmazie VL - 58 IS - 12 N2 - The behaviour of dorzolamide hydrochloride (DOR) was investigated at a glassy carbon electrode in different buffer systems using cyclic (CV), linear sweep (LSV) and differential pulse voltammetry (DPV). The oxidation process was found to be irreversible over the pH range studied (2.0-8.0) and was shown to be diffusion controlled. An analytical method with adequate precision and accuracy was developed for the determination of DOR in Britton-Robinson buffer (BRb) at pH = 3.06 containing 10% methanol as supporting electrolyte. The peak current varied linearly with DOR concentration in the range 4.0 x 10(-5)-6.0 x 10(-4) M. Furthermore, a HPLC method with diode array detection was developed. A calibration graph was established for 1.1 x 10(-6)-1.9 x 10(-4) M of DOR. The procedures were successfully applied for the determination of the drug in eye drops. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/14703963/Voltammetric_and_HPLC_determination_of_dorzolamide_hydrochloride_in_eye_drops_ DB - PRIME DP - Unbound Medicine ER -