Tags

Type your tag names separated by a space and hit enter

Erythrocyte redox status in streptozotocin diabetic rats: effect of Casearia esculenta root extract.
Pharmazie. 2003 Dec; 58(12):920-4.P

Abstract

The present study was aimed to investigate the effect of Casearia esculenta root extract on erythrocyte lipid peroxidation and to assess the status of antioxidants in red blood cells of streptozotocin (STZ) diabetic rats. The study showed a significant elevation (p < 0.05) of erythrocyte thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation and significant reduction (p < 0.05) in reduced glutathione (GSH), ascorbic acid (vitamin C), alpha-tocopherol (vitamin E), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the STZ diabetic rats. The study also observed significant reduction in membrane cholesterol and phospholipid content in STZ diabetic rats. By oral administration of C. esculenta (200 and 300 mg/kg body wt.) for 45 days to the diabetic rats these values approached almost normal levels. A dose of 300 mg/kg body weight C. esculenta extract showed better antioxidant effects than 200 mg/kg body weight.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamilnadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14703974

Citation

Prakasam, A, et al. "Erythrocyte Redox Status in Streptozotocin Diabetic Rats: Effect of Casearia Esculenta Root Extract." Die Pharmazie, vol. 58, no. 12, 2003, pp. 920-4.
Prakasam A, Sethupathy S, Pugalendi KV. Erythrocyte redox status in streptozotocin diabetic rats: effect of Casearia esculenta root extract. Pharmazie. 2003;58(12):920-4.
Prakasam, A., Sethupathy, S., & Pugalendi, K. V. (2003). Erythrocyte redox status in streptozotocin diabetic rats: effect of Casearia esculenta root extract. Die Pharmazie, 58(12), 920-4.
Prakasam A, Sethupathy S, Pugalendi KV. Erythrocyte Redox Status in Streptozotocin Diabetic Rats: Effect of Casearia Esculenta Root Extract. Pharmazie. 2003;58(12):920-4. PubMed PMID: 14703974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte redox status in streptozotocin diabetic rats: effect of Casearia esculenta root extract. AU - Prakasam,A, AU - Sethupathy,S, AU - Pugalendi,K V, PY - 2004/1/6/pubmed PY - 2004/1/30/medline PY - 2004/1/6/entrez SP - 920 EP - 4 JF - Die Pharmazie JO - Pharmazie VL - 58 IS - 12 N2 - The present study was aimed to investigate the effect of Casearia esculenta root extract on erythrocyte lipid peroxidation and to assess the status of antioxidants in red blood cells of streptozotocin (STZ) diabetic rats. The study showed a significant elevation (p < 0.05) of erythrocyte thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation and significant reduction (p < 0.05) in reduced glutathione (GSH), ascorbic acid (vitamin C), alpha-tocopherol (vitamin E), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the STZ diabetic rats. The study also observed significant reduction in membrane cholesterol and phospholipid content in STZ diabetic rats. By oral administration of C. esculenta (200 and 300 mg/kg body wt.) for 45 days to the diabetic rats these values approached almost normal levels. A dose of 300 mg/kg body weight C. esculenta extract showed better antioxidant effects than 200 mg/kg body weight. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/14703974/Erythrocyte_redox_status_in_streptozotocin_diabetic_rats:_effect_of_Casearia_esculenta_root_extract_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -