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A prospective controlled study of sleep respiratory events in patients with craniovertebral junction malformation.
J Neurosurg. 2003 Dec; 99(6):1004-9.JN

Abstract

OBJECT

Craniovertebral junction malformation (CVJM) or Chiari malformation in adults, with or without syringomyelia and basilar invagination, produces neuronal dysfunction of the brainstem, cerebellum, cranial nerves, and upper spinal cord. The respiratory center and some of its afferent and efferent components can be altered in these diseases. The authors studied patients with and without CVJM to determine whether this physical feature contributed to sleep disturbances.

METHODS

Respiratory manifestations during sleep were studied prospectively, by using whole-night polysomnography, in 32 symptomatic patients (CVJM group) and 16 healthy volunteers (control group). Patients with CVJM presented with more sleep disturbances (reports of snoring and apnea) than those in the control group. The apnea/hypopnea index values were higher in patients with CVJMs than in the control group (13 +/- 15 compared with 3 +/- 6; p = 0.007) and the rate of central sleep apneas was higher in the CVJM than in the control group (22 +/- 30 compared with 4 +/- 8%; p = 0.009). The apnea/hypopnea index was highest in the subgroup with basilar invagination than in the other subgroups. The central apneic episodes were more frequent in the patients with basilar invagination (35 +/- 40%; p = 0.001) and in those with syringomyelia (17.6 +/- 24.6%; p = 0.003) than in the control group (4 +/- 8%). Patients with symptomatic CVJM, especially those with basilar invagination, presented with more sleep respiratory compromise than did those in the control group.

CONCLUSIONS

The incidence of sleep apnea/hypopnea syndrome is significantly higher in patients with CVJM.

Authors+Show Affiliations

Department of Psychobiology, Sleep Institute, Universidade Federal de São Paulo, São Paulo, Brazil. bitbot@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14705728

Citation

Botelho, Ricardo Vieira, et al. "A Prospective Controlled Study of Sleep Respiratory Events in Patients With Craniovertebral Junction Malformation." Journal of Neurosurgery, vol. 99, no. 6, 2003, pp. 1004-9.
Botelho RV, Bittencourt LR, Rotta JM, et al. A prospective controlled study of sleep respiratory events in patients with craniovertebral junction malformation. J Neurosurg. 2003;99(6):1004-9.
Botelho, R. V., Bittencourt, L. R., Rotta, J. M., & Tufik, S. (2003). A prospective controlled study of sleep respiratory events in patients with craniovertebral junction malformation. Journal of Neurosurgery, 99(6), 1004-9.
Botelho RV, et al. A Prospective Controlled Study of Sleep Respiratory Events in Patients With Craniovertebral Junction Malformation. J Neurosurg. 2003;99(6):1004-9. PubMed PMID: 14705728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective controlled study of sleep respiratory events in patients with craniovertebral junction malformation. AU - Botelho,Ricardo Vieira, AU - Bittencourt,Lia Rita Azeredo, AU - Rotta,José Marcos, AU - Tufik,Sergio, PY - 2004/1/7/pubmed PY - 2004/2/11/medline PY - 2004/1/7/entrez SP - 1004 EP - 9 JF - Journal of neurosurgery JO - J Neurosurg VL - 99 IS - 6 N2 - OBJECT: Craniovertebral junction malformation (CVJM) or Chiari malformation in adults, with or without syringomyelia and basilar invagination, produces neuronal dysfunction of the brainstem, cerebellum, cranial nerves, and upper spinal cord. The respiratory center and some of its afferent and efferent components can be altered in these diseases. The authors studied patients with and without CVJM to determine whether this physical feature contributed to sleep disturbances. METHODS: Respiratory manifestations during sleep were studied prospectively, by using whole-night polysomnography, in 32 symptomatic patients (CVJM group) and 16 healthy volunteers (control group). Patients with CVJM presented with more sleep disturbances (reports of snoring and apnea) than those in the control group. The apnea/hypopnea index values were higher in patients with CVJMs than in the control group (13 +/- 15 compared with 3 +/- 6; p = 0.007) and the rate of central sleep apneas was higher in the CVJM than in the control group (22 +/- 30 compared with 4 +/- 8%; p = 0.009). The apnea/hypopnea index was highest in the subgroup with basilar invagination than in the other subgroups. The central apneic episodes were more frequent in the patients with basilar invagination (35 +/- 40%; p = 0.001) and in those with syringomyelia (17.6 +/- 24.6%; p = 0.003) than in the control group (4 +/- 8%). Patients with symptomatic CVJM, especially those with basilar invagination, presented with more sleep respiratory compromise than did those in the control group. CONCLUSIONS: The incidence of sleep apnea/hypopnea syndrome is significantly higher in patients with CVJM. SN - 0022-3085 UR - https://www.unboundmedicine.com/medline/citation/14705728/A_prospective_controlled_study_of_sleep_respiratory_events_in_patients_with_craniovertebral_junction_malformation_ L2 - https://thejns.org/doi/10.3171/jns.2003.99.6.1004 DB - PRIME DP - Unbound Medicine ER -