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Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis.
J Neurol Neurosurg Psychiatry 2004; 75(1):152-4JN

Abstract

BACKGROUND

Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology of multiple sclerosis. Previous studies show conflicting results.

OBJECTIVE

To investigate patients with multiple sclerosis and other neurological diseases for evidence of past or present infection with C pneumoniae.

METHODS

19 patients with multiple sclerosis and 29 with other neurological diseases were studied. Evidence was sought for past or present infection with C pneumoniae using polymerase chain reaction (PCR) and cell culture of cerebrospinal fluid (CSF), and enzyme linked immunosorbent assay and microimmunofluorescence of serum.

RESULTS

C pneumoniae was grown from the CSF of one patient with multiple sclerosis. PCR was negative in all cases. Anti-chlamydial antibodies were detected in the same proportion in each group.

CONCLUSIONS

This study does not support the theory of an association between C pneumoniae and multiple sclerosis.

Authors+Show Affiliations

Microbiology Department, University College London Hospitals, London WC1E 6DB, UK. SFurrows@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14707329

Citation

Furrows, S J., et al. "Chlamydophila Pneumoniae Infection of the Central Nervous System in Patients With Multiple Sclerosis." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 75, no. 1, 2004, pp. 152-4.
Furrows SJ, Hartley JC, Bell J, et al. Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2004;75(1):152-4.
Furrows, S. J., Hartley, J. C., Bell, J., Silver, N., Losseff, N., Stevenson, S., ... Giovannoni, G. (2004). Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry, 75(1), pp. 152-4.
Furrows SJ, et al. Chlamydophila Pneumoniae Infection of the Central Nervous System in Patients With Multiple Sclerosis. J Neurol Neurosurg Psychiatry. 2004;75(1):152-4. PubMed PMID: 14707329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis. AU - Furrows,S J, AU - Hartley,J C, AU - Bell,J, AU - Silver,N, AU - Losseff,N, AU - Stevenson,S, AU - Chapman,M, AU - Thompson,E J, AU - Ridgway,G L, AU - Giovannoni,G, PY - 2004/1/7/pubmed PY - 2004/2/5/medline PY - 2004/1/7/entrez SP - 152 EP - 4 JF - Journal of neurology, neurosurgery, and psychiatry JO - J. Neurol. Neurosurg. Psychiatry VL - 75 IS - 1 N2 - BACKGROUND: Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology of multiple sclerosis. Previous studies show conflicting results. OBJECTIVE: To investigate patients with multiple sclerosis and other neurological diseases for evidence of past or present infection with C pneumoniae. METHODS: 19 patients with multiple sclerosis and 29 with other neurological diseases were studied. Evidence was sought for past or present infection with C pneumoniae using polymerase chain reaction (PCR) and cell culture of cerebrospinal fluid (CSF), and enzyme linked immunosorbent assay and microimmunofluorescence of serum. RESULTS: C pneumoniae was grown from the CSF of one patient with multiple sclerosis. PCR was negative in all cases. Anti-chlamydial antibodies were detected in the same proportion in each group. CONCLUSIONS: This study does not support the theory of an association between C pneumoniae and multiple sclerosis. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/14707329/Chlamydophila_pneumoniae_infection_of_the_central_nervous_system_in_patients_with_multiple_sclerosis_ L2 - http://jnnp.bmj.com/cgi/pmidlookup?view=long&pmid=14707329 DB - PRIME DP - Unbound Medicine ER -