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[Results of an open multicenter study of the efficiency of one-week anti-helicobacter therapy using omeprazole, clarithromycin, and amoxicillin in patients with duodenal peptic ulcer].
Ter Arkh. 2003; 75(11):71-3.TA

Abstract

AIM

To study the efficiency of one-week antihelicobacter therapy using omeprazole, clarithromycin, and amoxycillin in patients with duodenal peptic ulcer during its recurrence.

MATERIALS AND METHODS

105 patients with recurrent peptic ulcer and a not less than 0.5-cm ulcer in the duodenal bulb was given triple therapy: omeprazole, 20 mg twice daily, amoxycillin, 1000 mg twice daily, and clarithromycin, 500 mg twice daily for 7 days. Then the patients were allowed to take antacids if they were required to abolish the symptoms of recurrent peptic ulcer. H. pylori was detected in the mucosal biopsy specimens taken from the anthral part and body of the stomach at gastroduodenascopy, by using the rapid urease test and histology. Gastroduodenoscopy was performed before and 4-6 weeks after the triple therapy.

RESULTS

The major symptoms of recurrent peptic ulcer were eliminated in 90% of the patients by the end of a course of therapy, i.e. on its day 7. By the control time, the rate of ulcer cicatrization was 99.05% (104/105). The coincidence of results of the two tests has indicated that H. pylori eradication was 81.9% (86/105) 4-6 weeks after termination of treatment. Adverse reactions during therapy were observed in 20% of the patients; however, treatment had to be discontinued only in 2.9% of the patients.

CONCLUSION

One-week triple therapy using omeprazole, clarithromycin, and amoxycillin in highly effective in treating duodenal peptic ulcer during its recurrence.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

rus

PubMed ID

14708448

Citation

Isakov, V A., et al. "[Results of an Open Multicenter Study of the Efficiency of One-week Anti-helicobacter Therapy Using Omeprazole, Clarithromycin, and Amoxicillin in Patients With Duodenal Peptic Ulcer]." Terapevticheskii Arkhiv, vol. 75, no. 11, 2003, pp. 71-3.
Isakov VA, Maev IV, Simanenkov VI, et al. [Results of an open multicenter study of the efficiency of one-week anti-helicobacter therapy using omeprazole, clarithromycin, and amoxicillin in patients with duodenal peptic ulcer]. Ter Arkh. 2003;75(11):71-3.
Isakov, V. A., Maev, I. V., Simanenkov, V. I., Kononov, A. V., Abdulkhakov, R. A., Zakharova, N. V., Livzan, M. A., & Predvechnaia, I. K. (2003). [Results of an open multicenter study of the efficiency of one-week anti-helicobacter therapy using omeprazole, clarithromycin, and amoxicillin in patients with duodenal peptic ulcer]. Terapevticheskii Arkhiv, 75(11), 71-3.
Isakov VA, et al. [Results of an Open Multicenter Study of the Efficiency of One-week Anti-helicobacter Therapy Using Omeprazole, Clarithromycin, and Amoxicillin in Patients With Duodenal Peptic Ulcer]. Ter Arkh. 2003;75(11):71-3. PubMed PMID: 14708448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Results of an open multicenter study of the efficiency of one-week anti-helicobacter therapy using omeprazole, clarithromycin, and amoxicillin in patients with duodenal peptic ulcer]. AU - Isakov,V A, AU - Maev,I V, AU - Simanenkov,V I, AU - Kononov,A V, AU - Abdulkhakov,R A, AU - Zakharova,N V, AU - Livzan,M A, AU - Predvechnaia,I K, PY - 2004/1/8/pubmed PY - 2004/5/1/medline PY - 2004/1/8/entrez SP - 71 EP - 3 JF - Terapevticheskii arkhiv JO - Ter Arkh VL - 75 IS - 11 N2 - AIM: To study the efficiency of one-week antihelicobacter therapy using omeprazole, clarithromycin, and amoxycillin in patients with duodenal peptic ulcer during its recurrence. MATERIALS AND METHODS: 105 patients with recurrent peptic ulcer and a not less than 0.5-cm ulcer in the duodenal bulb was given triple therapy: omeprazole, 20 mg twice daily, amoxycillin, 1000 mg twice daily, and clarithromycin, 500 mg twice daily for 7 days. Then the patients were allowed to take antacids if they were required to abolish the symptoms of recurrent peptic ulcer. H. pylori was detected in the mucosal biopsy specimens taken from the anthral part and body of the stomach at gastroduodenascopy, by using the rapid urease test and histology. Gastroduodenoscopy was performed before and 4-6 weeks after the triple therapy. RESULTS: The major symptoms of recurrent peptic ulcer were eliminated in 90% of the patients by the end of a course of therapy, i.e. on its day 7. By the control time, the rate of ulcer cicatrization was 99.05% (104/105). The coincidence of results of the two tests has indicated that H. pylori eradication was 81.9% (86/105) 4-6 weeks after termination of treatment. Adverse reactions during therapy were observed in 20% of the patients; however, treatment had to be discontinued only in 2.9% of the patients. CONCLUSION: One-week triple therapy using omeprazole, clarithromycin, and amoxycillin in highly effective in treating duodenal peptic ulcer during its recurrence. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/14708448/[Results_of_an_open_multicenter_study_of_the_efficiency_of_one_week_anti_helicobacter_therapy_using_omeprazole_clarithromycin_and_amoxicillin_in_patients_with_duodenal_peptic_ulcer]_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -