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The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: a double-blind placebo-controlled trial.
J Clin Psychopharmacol. 2004 Feb; 24(1):83-6.JC

Abstract

Free radicals may be involved in the pathogenesis of tardive dyskinesia (TD). Vitamin E, a free radical scavenger, has been reported to improve symptoms of TD. The present study was designed to replicate this finding in a group of Chinese patients with TD, and to examine the effect of vitamin E treatment on blood superoxide dismutase (SOD), a critical enzyme in the detoxification of free radicals. Forty-one inpatients with TD completed a double-blind, placebo-controlled, parallel-group study of vitamin E. Twenty-two of the patients were randomly assigned to receive a fixed dose of 1200 IU/d vitamin E, and 19 were assigned to a placebo for 12 weeks. Patients were assessed primarily using the Abnormal Involuntary Movement Scale (AIMS) at baseline, weeks 6 and 12. Blood SOD levels were measured by radioimmunometric assay before and after treatment. The results showed that the reduction in AIMS score from baseline was significantly higher with vitamin E treatment compared with placebo (45.9% vs. 4.3%). Blood SOD levels were significantly increased after treatment with vitamin E (P = 0.001), but no change with placebo treatment (P < 0.05). These results support earlier findings of the efficacy of vitamin E in the treatment of TD. Moreover, the efficacy of vitamin E may be due to its ability to increase SOD level, which may reduce oxidative injure in tardive dyskinesia.

Authors+Show Affiliations

Institute of Mental Health, Peking University, 100083 Beijing, China; dagger Beijing Hui-Long-Guan Hospital, 100096 Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14709952

Citation

Zhang, Xiang Yang, et al. "The Effect of Vitamin E Treatment On Tardive Dyskinesia and Blood Superoxide Dismutase: a Double-blind Placebo-controlled Trial." Journal of Clinical Psychopharmacology, vol. 24, no. 1, 2004, pp. 83-6.
Zhang XY, Zhou DF, Cao LY, et al. The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: a double-blind placebo-controlled trial. J Clin Psychopharmacol. 2004;24(1):83-6.
Zhang, X. Y., Zhou, D. F., Cao, L. Y., Xu, C. Q., Chen, D. C., & Wu, G. Y. (2004). The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: a double-blind placebo-controlled trial. Journal of Clinical Psychopharmacology, 24(1), 83-6.
Zhang XY, et al. The Effect of Vitamin E Treatment On Tardive Dyskinesia and Blood Superoxide Dismutase: a Double-blind Placebo-controlled Trial. J Clin Psychopharmacol. 2004;24(1):83-6. PubMed PMID: 14709952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: a double-blind placebo-controlled trial. AU - Zhang,Xiang Yang, AU - Zhou,Dong Feng, AU - Cao,Lian Yuan, AU - Xu,Chang Qing, AU - Chen,Da Chun, AU - Wu,Gui Ying, PY - 2004/1/8/pubmed PY - 2004/6/18/medline PY - 2004/1/8/entrez SP - 83 EP - 6 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 24 IS - 1 N2 - Free radicals may be involved in the pathogenesis of tardive dyskinesia (TD). Vitamin E, a free radical scavenger, has been reported to improve symptoms of TD. The present study was designed to replicate this finding in a group of Chinese patients with TD, and to examine the effect of vitamin E treatment on blood superoxide dismutase (SOD), a critical enzyme in the detoxification of free radicals. Forty-one inpatients with TD completed a double-blind, placebo-controlled, parallel-group study of vitamin E. Twenty-two of the patients were randomly assigned to receive a fixed dose of 1200 IU/d vitamin E, and 19 were assigned to a placebo for 12 weeks. Patients were assessed primarily using the Abnormal Involuntary Movement Scale (AIMS) at baseline, weeks 6 and 12. Blood SOD levels were measured by radioimmunometric assay before and after treatment. The results showed that the reduction in AIMS score from baseline was significantly higher with vitamin E treatment compared with placebo (45.9% vs. 4.3%). Blood SOD levels were significantly increased after treatment with vitamin E (P = 0.001), but no change with placebo treatment (P < 0.05). These results support earlier findings of the efficacy of vitamin E in the treatment of TD. Moreover, the efficacy of vitamin E may be due to its ability to increase SOD level, which may reduce oxidative injure in tardive dyskinesia. SN - 0271-0749 UR - https://www.unboundmedicine.com/medline/citation/14709952/The_effect_of_vitamin_E_treatment_on_tardive_dyskinesia_and_blood_superoxide_dismutase:_a_double_blind_placebo_controlled_trial_ L2 - http://dx.doi.org/10.1097/01.jcp.0000104912.75206.2b DB - PRIME DP - Unbound Medicine ER -