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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
Nature. 2004 Jan 15; 427(6971):260-5.Nat

Abstract

Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory nerve endings, thereby producing pain, inflammation and robust hypersensitivity to thermal and mechanical stimuli. Despite their widespread use in both the kitchen and the laboratory, the molecular mechanism through which isothiocyanates mediate their effects remains unknown. Here we show that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Both allyl isothiocyanate and THC mediate their excitatory effects by activating ANKTM1, a member of the TRP ion channel family recently implicated in the detection of noxious cold. These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors.

Authors+Show Affiliations

Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143-2140, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14712238

Citation

Jordt, Sven-Eric, et al. "Mustard Oils and Cannabinoids Excite Sensory Nerve Fibres Through the TRP Channel ANKTM1." Nature, vol. 427, no. 6971, 2004, pp. 260-5.
Jordt SE, Bautista DM, Chuang HH, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004;427(6971):260-5.
Jordt, S. E., Bautista, D. M., Chuang, H. H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. (2004). Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature, 427(6971), 260-5.
Jordt SE, et al. Mustard Oils and Cannabinoids Excite Sensory Nerve Fibres Through the TRP Channel ANKTM1. Nature. 2004 Jan 15;427(6971):260-5. PubMed PMID: 14712238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. AU - Jordt,Sven-Eric, AU - Bautista,Diana M, AU - Chuang,Huai-Hu, AU - McKemy,David D, AU - Zygmunt,Peter M, AU - Högestätt,Edward D, AU - Meng,Ian D, AU - Julius,David, Y1 - 2004/01/07/ PY - 2003/12/02/received PY - 2003/12/12/accepted PY - 2004/1/9/pubmed PY - 2004/2/3/medline PY - 2004/1/9/entrez SP - 260 EP - 5 JF - Nature JO - Nature VL - 427 IS - 6971 N2 - Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory nerve endings, thereby producing pain, inflammation and robust hypersensitivity to thermal and mechanical stimuli. Despite their widespread use in both the kitchen and the laboratory, the molecular mechanism through which isothiocyanates mediate their effects remains unknown. Here we show that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by Delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Both allyl isothiocyanate and THC mediate their excitatory effects by activating ANKTM1, a member of the TRP ion channel family recently implicated in the detection of noxious cold. These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/14712238/Mustard_oils_and_cannabinoids_excite_sensory_nerve_fibres_through_the_TRP_channel_ANKTM1_ L2 - https://doi.org/10.1038/nature02282 DB - PRIME DP - Unbound Medicine ER -